{"doi":"10.1016/j.bmcl.2021.127778","title":"Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2021,"id":14065,"datarank":0.4096185550871797,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.11773203272888269,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.11773203272888269,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":112749,"name":"Peter K. Park","orcid":"0000-0003-3201-117X","position":1,"is_corresponding":false},{"id":112750,"name":"Donna Wei","orcid":null,"position":2,"is_corresponding":false},{"id":112751,"name":"Ashok Purandare","orcid":null,"position":3,"is_corresponding":false},{"id":112752,"name":"Honghe Wan","orcid":null,"position":4,"is_corresponding":false},{"id":112753,"name":"Daniel O'Malley","orcid":null,"position":5,"is_corresponding":false},{"id":112754,"name":"Sylwia Stachura","orcid":null,"position":6,"is_corresponding":false},{"id":112755,"name":"Heidi Perez","orcid":null,"position":7,"is_corresponding":false},{"id":112756,"name":"Cullen L. Cavallaro","orcid":"0000-0001-9498-2612","position":8,"is_corresponding":false},{"id":112757,"name":"Carolyn A. Weigelt","orcid":null,"position":9,"is_corresponding":false},{"id":112758,"name":"John S. Sack","orcid":"0000-0003-1542-9515","position":10,"is_corresponding":false},{"id":112759,"name":"Max Ruzanov","orcid":null,"position":11,"is_corresponding":false},{"id":66995,"name":"Javed Khan","orcid":null,"position":12,"is_corresponding":false},{"id":112760,"name":"Murali Gururajan","orcid":null,"position":13,"is_corresponding":false},{"id":112761,"name":"Jessica J. Wong","orcid":null,"position":14,"is_corresponding":false},{"id":112762,"name":"Yanling Huang","orcid":null,"position":15,"is_corresponding":false},{"id":112763,"name":"Melissa Yarde","orcid":null,"position":16,"is_corresponding":false},{"id":112764,"name":"Zhuyin Li","orcid":null,"position":17,"is_corresponding":false},{"id":112765,"name":"Cliff Chen","orcid":null,"position":18,"is_corresponding":false},{"id":112766,"name":"Huadong Sun","orcid":null,"position":19,"is_corresponding":false},{"id":112767,"name":"Virna Borowski","orcid":null,"position":20,"is_corresponding":false},{"id":112768,"name":"Jenny H. Xie","orcid":null,"position":21,"is_corresponding":false},{"id":112769,"name":"Monique Anthony","orcid":null,"position":22,"is_corresponding":false},{"id":112770,"name":"Michele Agler","orcid":null,"position":23,"is_corresponding":false},{"id":112771,"name":"Brian E. Fink","orcid":null,"position":24,"is_corresponding":false},{"id":112772,"name":"Lalgudi S. Harikrishnan","orcid":"0000-0002-4976-2933","position":25,"is_corresponding":false},{"id":112748,"name":"Zheming Ruan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33422603","pmcid":null,"openalex_id":"https://openalex.org/W3120914134","authors":[],"funders":[],"total_grants":0,"fwci":0.4092,"citation_percentile":0.55973377,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":3},{"year":2025,"count":1}],"oa_status":"green","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://doi.org/10.7270/q2q52t84","host_type":"repository"},{"url":"https://doi.org/10.7270/q2q52t84","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X21000044?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X21000044?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2021.127778","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33422603","host_type":"repository"}],"fields_of_study":["Psoriasis: Treatment and Pathogenesis","Retinoids in leukemia and cellular processes","Sphingolipid Metabolism and Signaling","Medicine","Chemistry","Animals","Crystallography, X-Ray","Dose-Response Relationship, Drug","Ethers","Humans","Mice","Models, Molecular","Molecular Structure","Nuclear Receptor Subfamily 1, Group F, Member 3","Structure-Activity Relationship","Th17 Cells","Tretinoin"],"mesh_terms":["Animals","Dose-Response Relationship, Drug","Ethers","Humans","Models, Molecular","Structure-Activity Relationship","Tretinoin","Molecular Structure","Crystallography, X-Ray","Mice","Nuclear Receptor Subfamily 1, Group F, Member 3","Th17 Cells"],"keywords":["Orphan receptor","Chemistry","Retinoic acid","RAR-related orphan receptor gamma","Agonist","Retinoic acid receptor","Potency","Pharmacology","Lead compound","Nuclear receptor","Pharmacokinetics","Stereochemistry","Receptor","Biochemistry","In vitro","Medicine","Rorγt","Rorgt","Ror Gamma","Th 17 Cells And Il-17","Retinoic Acid Related-orphan Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T00:29:54.241048Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}