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Herein we presented a series of novel phenoxybenzamide analogues with inhibition of Raf and HDAC. Among them, compound 10e showed potent antiproliferative activities against Hepg2 and MDA-MB-468 in cellular assays. This work may lay the foundation for developing novel dual Raf/HDAC inhibitors as potential anticancer therapeutics.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31053508","pmcid":null,"openalex_id":"https://openalex.org/W2943680208","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81803033","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"CPU2018GF02","title":null}],"total_grants":2,"fwci":0.9109,"citation_percentile":0.72703508,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":6},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2025,"count":2}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://doi.org/10.7270/q29p352d","host_type":"repository"},{"url":"https://doi.org/10.7270/q29p352d","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X1930280X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X1930280X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2019.04.047","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31053508","host_type":"repository"}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Protein Degradation and Inhibitors","Peptidase Inhibition and Analysis","Histone Deacetylase Inhibitors","Humans","Phenoxybenzamine","Structure-Activity Relationship"],"mesh_terms":["Humans","Phenoxybenzamine","Structure-Activity Relationship","Histone Deacetylase Inhibitors"],"keywords":["Histone deacetylase","Chemistry","Epigenetics","Acetylation","Histone","Kinase","Biochemistry","Gene","Antiproliferative Activity","Hdac","Raf","Dual Inhibitor","Phenoxybenzamide"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.7270/q29p352d","title":"BindingDB Entry 50008932: Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors.","publisher":"BindingDB","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T17:11:01.028544Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}