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In vivo evaluations found 6 to be well tolerated, of high therapeutic efficacy and of low systemic toxicity, at effective doses. The results suggest 6 to be a promising lead for future study, and the use of multiple isoquinoline-3-carboxylic acid moieties as pharmacophores in the same molecule to be a useful strategy for the design of anti-tumor drugs.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26386603","pmcid":null,"openalex_id":"https://openalex.org/W1629846073","authors":[],"funders":[{"funder_name":"Beijing Municipal Science & Technology Commission","grant_id":"Z141100002114049","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"21103115","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81172930","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81273379","title":null},{"funder_name":"Beijing Natural Science Foundation","grant_id":"7132032","title":null}],"total_grants":5,"fwci":0.3084,"citation_percentile":0.55791332,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0960894X15300482?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X15300482?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2015.09.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26386603","host_type":"repository"}],"fields_of_study":["Synthesis and Biological Activity","Cancer therapeutics and mechanisms"],"mesh_terms":["Animals","Antineoplastic Agents","Benzoates","Dose-Response Relationship, Drug","Drug Screening Assays, Antitumor","Humans","Isoquinolines","Neoplasms, Experimental","Structure-Activity Relationship","Drug Design","Molecular Structure","Cell Line, Tumor","Cell Proliferation","Mice"],"keywords":["Isoquinoline","Chemistry","Pharmacophore","Carboxylic acid","Lead compound","Benzoic acid","Amine gas treating","Combinatorial chemistry","In vivo","Conjugated system","Stereochemistry","Pharmacology","Organic chemistry","In vitro","Biochemistry","Polymer","Anti-tumor","Tris(2-aminoethyl)amine","Isoquinoline-3-carboxylic Acid","Multiple Pharmacophores"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T14:34:15.983898Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}