{"doi":"10.1016/j.bmcl.2014.04.111","title":"The enone motif of (+)-grandifloracin is not essential for ‘anti-austerity’ antiproliferative activity","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2014,"id":652908,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1703427,"name":"Pauline J. Wood","orcid":null,"position":1,"is_corresponding":false},{"id":1703428,"name":"Natasha M. Lamb-Guhren","orcid":null,"position":2,"is_corresponding":false},{"id":1703429,"name":"Lorenzo Caggiano","orcid":"0000-0003-0805-3118","position":3,"is_corresponding":false},{"id":1703430,"name":"Gabriele Kociok-Köhn","orcid":null,"position":4,"is_corresponding":false},{"id":148175,"name":"David Tosh","orcid":null,"position":5,"is_corresponding":false},{"id":1703431,"name":"Simon E. Lewis","orcid":null,"position":6,"is_corresponding":false},{"id":1703426,"name":"Monika Ali Khan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The enone motif of (+)-grandifloracin is not essential for ‘anti-austerity’ antiproliferative activity","abstract":"We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the natural product. The retention of activity in an analogue lacking the enone functional group, 9, implies this structural element is not an essential part of the (+)-grandifloracin pharmacophore.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24835628","pmcid":null,"openalex_id":"https://openalex.org/W2137962088","authors":[],"funders":[{"funder_name":"HEFCE Higher Education Innovation Fund","grant_id":"","title":null},{"funder_name":"University of Bath RDSO","grant_id":"","title":null}],"total_grants":2,"fwci":1.04,"citation_percentile":0.75798187,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0960894X14004685/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0960894X14004685/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X14004685?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X14004685?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2014.04.111","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24835628","host_type":"repository"},{"url":"https://researchportal.bath.ac.uk/en/publications/0533a043-965d-4d14-adb0-b5c88b3adb3d","host_type":"repository"},{"url":"http://opus.bath.ac.uk/39867/1/Published_version.pdf","host_type":"repository"},{"url":"http://www.scopus.com/inward/record.url?scp=84901802206&partnerID=8YFLogxK","host_type":"repository"}],"fields_of_study":["Signaling Pathways in Disease","DNA Repair Mechanisms","Drug Transport and Resistance Mechanisms","Antineoplastic Agents, Phytogenic","Bridged-Ring Compounds","Cell Line, Tumor","Cell Proliferation","Crystallography, X-Ray","Dose-Response Relationship, Drug","Drug Screening Assays, Antitumor","HT29 Cells","Humans","Ketones","Models, Molecular","Molecular Structure","Stereoisomerism","Structure-Activity Relationship","Uvaria"],"mesh_terms":["Antineoplastic Agents, Phytogenic","Bridged-Ring Compounds","Dose-Response Relationship, Drug","Drug Screening Assays, Antitumor","Humans","Ketones","Models, Molecular","Stereoisomerism","Structure-Activity Relationship","Molecular Structure","Crystallography, X-Ray","HT29 Cells","Uvaria","Cell Line, Tumor","Cell Proliferation"],"keywords":["Chemistry","Enone","Natural product","Pharmacophore","Stereochemistry","Biological activity","Structural motif","Chemical synthesis","Biochemistry","In vitro","Natural products","Pancreatic cancer","Antiproliferative","Analogue Synthesis","Organoiron Chemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:25:59.088647Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}