{"doi":"10.1016/j.bmcl.2010.11.041","title":"In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2011,"id":639868,"datarank":3.2750296121556963,"base_score":4.143134726391533,"endowment":4.143134726391533,"self_citation_contribution":0.62147020895873,"citation_network_contribution":2.6535594031969665,"self_endowment_contribution":0.62147020895873,"citer_contribution":2.6535594031969665,"corpus_percentile":null,"corpus_rank":null,"citation_count":62,"citer_count":56,"citers_with_citation_signal":53,"citers_with_endowment":53,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1388016,"name":"Antonella Del Corso","orcid":"0000-0003-3165-6128","position":1,"is_corresponding":false},{"id":1662805,"name":"Marco Giglio","orcid":null,"position":2,"is_corresponding":false},{"id":1388015,"name":"Roberta Moschini","orcid":"0000-0001-5227-2348","position":3,"is_corresponding":false},{"id":1662806,"name":"Umberto Mura","orcid":null,"position":4,"is_corresponding":false},{"id":1662807,"name":"Rosaria Ottanà","orcid":null,"position":5,"is_corresponding":false},{"id":1662804,"name":"Rosanna Maccari","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors","abstract":"2-Thioxo-4-thiazolidinone derivatives were evaluated as aldose reductase inhibitors (ARIs) and most of them exhibited good or excellent in vitro efficacy. Out of the tested compounds, most N-unsubstituted analogues were found to possess inhibitory effects at low micromolar doses and two of them exhibited higher potency than sorbinil, used as a reference drug. The insertion of an acetic chain on N-3 of the thiazolidinone scaffold led to analogues with submicromolar affinity for ALR2 and IC(50) values very similar to that of epalrestat, the only ARI currently used in therapy.","is_dataset_classified":null,"base_score":4.143134726391533,"endowment":4.143134726391533,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21129963","pmcid":null,"openalex_id":"https://openalex.org/W2082404553","authors":[],"funders":[{"funder_name":"Università degli Studi di Messina","grant_id":"","title":null},{"funder_name":"Università di Pisa","grant_id":"","title":null}],"total_grants":2,"fwci":1.9908,"citation_percentile":0.85099498,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":4},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":8},{"year":2022,"count":5},{"year":2023,"count":7},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"green","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://doi.org/10.7270/q2zp46c4","host_type":"repository"},{"url":"https://doi.org/10.7270/q2zp46c4","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X10016537?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X10016537?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2010.11.041","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21129963","host_type":"repository"},{"url":"http://hdl.handle.net/11568/193560","host_type":"repository"}],"fields_of_study":["Aldose Reductase and Taurine","Advanced Glycation End Products research","Biochemical Acid Research Studies","Aldehyde Reductase","Animals","Cattle","Enzyme Inhibitors","Imidazolidines","Structure-Activity Relationship","Thiazolidinediones"],"mesh_terms":["Aldehyde Reductase","Animals","Cattle","Enzyme Inhibitors","Structure-Activity Relationship","Thiazolidinediones","Imidazolidines"],"keywords":["Aldose reductase","Chemistry","Sorbinil","Aldose reductase inhibitor","Aldehyde Reductase","In vitro","Potency","Stereochemistry","IC50","Enzyme inhibitor","Enzyme","Pharmacology","Biochemistry"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.7270/q2zp46c4","title":"BindingDB Entry 50032752: In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.","publisher":"BindingDB","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T03:27:29.114842Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}