{"doi":"10.1016/j.bmcl.2009.04.058","title":"Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2009,"id":651347,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1384730,"name":"Rong He","orcid":"0009-0001-5611-7078","position":1,"is_corresponding":false},{"id":1698624,"name":"Doris N. Luchini","orcid":null,"position":2,"is_corresponding":false},{"id":145480,"name":"Daniel D. Billadeau","orcid":null,"position":3,"is_corresponding":false},{"id":188999,"name":"Alan P. Kozikowski","orcid":null,"position":4,"is_corresponding":false},{"id":384270,"name":"Subhasish Tapadar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity","abstract":"A series of hydroxamic acid based histone deacetylase inhibitors 6-15, containing an isoxazole moiety adjacent to the Zn-chelating hydroxamic acid, is reported herein. Some of these compounds showed nanomolar activity in the HDAC isoform inhibitory assay and exhibited micro molar inhibitory activity against five pancreatic cancer cell lines.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19419863","pmcid":null,"openalex_id":"https://openalex.org/W2011419862","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P50 CA102701","title":null}],"total_grants":1,"fwci":0.6299,"citation_percentile":0.6640632,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":6},{"year":2014,"count":2},{"year":2015,"count":5},{"year":2016,"count":2},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":6},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2026,"count":2}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2705901","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2705901","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X09005149?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X09005149?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2009.04.058","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19419863","host_type":"repository"},{"url":"https://doi.org/10.7270/q2833rxg","host_type":"repository"}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Peptidase Inhibition and Analysis","Protein Degradation and Inhibitors","Antineoplastic Agents","Cell Line, Tumor","Enzyme Inhibitors","Histone Deacetylase Inhibitors","Histone Deacetylases","Humans","Hydroxamic Acids","Isoxazoles","Zinc"],"mesh_terms":["Antineoplastic Agents","Enzyme Inhibitors","Histone Deacetylases","Humans","Hydroxamic Acids","Isoxazoles","Zinc","Cell Line, Tumor","Histone Deacetylase Inhibitors"],"keywords":["Isoxazole","Hydroxamic acid","Moiety","Chemistry","Histone deacetylase","Linker","Vorinostat","Chelation","Stereochemistry","Cell culture","Biochemistry","Histone","Organic chemistry","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T07:49:46.957271Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}