{"doi":"10.1016/j.bmcl.2007.01.011","title":"Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2007,"id":607390,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":113902,"name":"Hidehiko Nakagawa","orcid":null,"position":1,"is_corresponding":false},{"id":111414,"name":"Takayoshi Suzuki","orcid":null,"position":2,"is_corresponding":false},{"id":111416,"name":"Naoki Miyata","orcid":null,"position":3,"is_corresponding":false},{"id":1559604,"name":"Shizuka Ban","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria","abstract":"Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, and apoptosis, are thought to be associated with oxidative stress affecting mitochondria. In this study, we designed and synthesized a fluorescein-tagged TEMPO derivative, compound 1, with triphenylphosphino moiety. Synthesized 1 localized in mitochondria and detected oxidative stress in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress in mitochondria.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17275296","pmcid":null,"openalex_id":"https://openalex.org/W2022376905","authors":[],"funders":[],"total_grants":0,"fwci":0.6662,"citation_percentile":0.67761018,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":3},{"year":2014,"count":1},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0960894X07000480?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X07000480?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2007.01.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17275296","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Metabolism and Genetic Disorders","ATP Synthase and ATPases Research","Animals","Cell Line","Chemistry, Pharmaceutical","Cyclic N-Oxides","Drug Design","Electron Spin Resonance Spectroscopy","Mice","Mitochondria","Models, Chemical","Molecular Conformation","Oxidative Stress","Time Factors"],"mesh_terms":["Animals","Cell Line","Chemistry, Pharmaceutical","Cyclic N-Oxides","Electron Spin Resonance Spectroscopy","Mitochondria","Models, Chemical","Molecular Conformation","Time Factors","Drug Design","Oxidative Stress","Mice"],"keywords":["Mitochondrion","Oxidative stress","Chemistry","Oxidative phosphorylation","Apoptosis","Moiety","Derivative (finance)","Cell biology","Biochemistry","Stereochemistry","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:18:43.020713Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}