{"doi":"10.1016/j.bmcl.2006.05.036","title":"Estrogen receptor β-subtype selective tetrahydrofluorenones: Use of a fused pyrazole as a phenol bioisostere","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2006,"id":672338,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1756635,"name":"R.W. Ratcliffe","orcid":null,"position":1,"is_corresponding":false},{"id":1756636,"name":"A.K. Fried","orcid":null,"position":2,"is_corresponding":false},{"id":1756637,"name":"D. Meng","orcid":null,"position":3,"is_corresponding":false},{"id":26938,"name":"W. Sun","orcid":"0000-0003-4002-0199","position":4,"is_corresponding":false},{"id":1756638,"name":"L. Colwell","orcid":null,"position":5,"is_corresponding":false},{"id":803577,"name":"S. Lambert","orcid":null,"position":6,"is_corresponding":false},{"id":1756639,"name":"M. Greenlee","orcid":null,"position":7,"is_corresponding":false},{"id":1756640,"name":"S. Nilsson","orcid":null,"position":8,"is_corresponding":false},{"id":1756641,"name":"A. Thorsell","orcid":null,"position":9,"is_corresponding":false},{"id":1756642,"name":"M. Mojena","orcid":null,"position":10,"is_corresponding":false},{"id":1756643,"name":"C. Tudela","orcid":null,"position":11,"is_corresponding":false},{"id":1756644,"name":"K. Frisch","orcid":null,"position":12,"is_corresponding":false},{"id":1756645,"name":"W. Chan","orcid":null,"position":13,"is_corresponding":false},{"id":1756646,"name":"E.T. Birzin","orcid":null,"position":14,"is_corresponding":false},{"id":1756647,"name":"S.P. Rohrer","orcid":null,"position":15,"is_corresponding":false},{"id":1756648,"name":"M.L. Hammond","orcid":null,"position":16,"is_corresponding":false},{"id":1756634,"name":"R.R. Wilkening","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Estrogen receptor β-subtype selective tetrahydrofluorenones: Use of a fused pyrazole as a phenol bioisostere","abstract":"Synthesis of a series of fused pyrazole tetrahydrofluorenone analogs which are potent, ERbeta subtype selective ligands is described. Analogs possessing subnanomolar ERbeta binding, greater than 100-fold ERbeta-selectivity, and oral bioavailability are reported.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16730987","pmcid":null,"openalex_id":"https://openalex.org/W2175203739","authors":[],"funders":[],"total_grants":0,"fwci":2.2208,"citation_percentile":0.88292672,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2022,"count":2},{"year":2025,"count":3}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://doi.org/10.7270/q24t6j01","host_type":"repository"},{"url":"https://doi.org/10.7270/q24t6j01","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X06005798?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X06005798?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2006.05.036","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16730987","host_type":"repository"}],"fields_of_study":["Estrogen and related hormone effects","Cytokine Signaling Pathways and Interactions","Bioactive Compounds and Antitumor Agents","Animals","Area Under Curve","Biological Availability","Cyclization","Estrogen Receptor beta","Fluorenes","Pyrazoles","Rats"],"mesh_terms":["Animals","Biological Availability","Cyclization","Fluorenes","Pyrazoles","Area Under Curve","Estrogen Receptor beta","Rats"],"keywords":["Bioisostere","Chemistry","Pyrazole","Bioavailability","Selectivity","Chemical synthesis","Estrogen receptor","Stereochemistry","Phenol","Selective estrogen receptor modulator","Estrogen","Combinatorial chemistry","Carboxamide","Structure–activity relationship","Pharmacology","In vitro","Biochemistry","Internal medicine","Organic chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T08:42:30.349781Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}