{"doi":"10.1016/j.bmc.2016.01.047","title":"Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives","abstract":null,"journal":"Bioorganic & Medicinal Chemistry","year":2016,"id":662376,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1729159,"name":"Lisa I. 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The most potent eight compounds were active against all cell lines with IC50 values in the 80-250nM range. In general hexahydrocycloocta[b]thieno[3,2-e]pyridines were most active with increasing activity observed as larger cycloalkyl rings were fused to the pyridine ring.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26853836","pmcid":null,"openalex_id":"https://openalex.org/W2282590766","authors":[],"funders":[{"funder_name":"Auckland Medical Research Foundation","grant_id":"","title":null},{"funder_name":"Auckland Cancer Society","grant_id":"","title":null},{"funder_name":"Auckland Cancer Society Research Centre","grant_id":"","title":null},{"funder_name":"University of Auckland","grant_id":"","title":null}],"total_grants":4,"fwci":1.8154,"citation_percentile":0.84975239,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2021,"count":7},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0968089616300621?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968089616300621?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmc.2016.01.047","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26853836","host_type":"repository"},{"url":"https://hdl.handle.net/2292/32606","host_type":"repository"}],"fields_of_study":["Synthesis and biological activity","Synthesis and Biological Evaluation","Bioactive Compounds and Antitumor Agents","Antineoplastic Agents","Cell Line, Tumor","Cell Proliferation","Drug Screening Assays, Antitumor","Humans","Neoplasms","Quinolines","Structure-Activity Relationship","Thienopyridines"],"mesh_terms":["Antineoplastic Agents","Drug Screening Assays, Antitumor","Humans","Neoplasms","Quinolines","Structure-Activity Relationship","Cell Line, Tumor","Cell Proliferation","Thienopyridines"],"keywords":["Chemistry","Quinoline","Pyridine","Carboxamide","Stereochemistry","Cytotoxicity","Ring (chemistry)","Chemical synthesis","IC50","In vitro","Medicinal chemistry","Organic chemistry","Biochemistry","Antiproliferative","Thieno[2,3-b]pyridines","Thieno[2,3-b]quinolones","Thieno[3,2-e]pyridines"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T14:17:49.160099Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}