{"doi":"10.1016/j.bmc.2014.09.029","title":"Discovery of 4-aminoquinazoline—urea derivatives as Aurora kinase inhibitors with antiproliferative activity","abstract":null,"journal":"Bioorganic & Medicinal Chemistry","year":2014,"id":606025,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":746341,"name":"Lili Li","orcid":"0000-0002-8888-153X","position":1,"is_corresponding":false},{"id":1041780,"name":"Kwon Ho Hong","orcid":"0000-0001-8787-324X","position":2,"is_corresponding":false},{"id":274865,"name":"Xiaoqing Wu","orcid":"0000-0003-2076-4107","position":3,"is_corresponding":false},{"id":1555572,"name":"Junqing Chen","orcid":null,"position":4,"is_corresponding":false},{"id":1419920,"name":"Peng Wang","orcid":"0000-0002-7013-2039","position":5,"is_corresponding":false},{"id":960250,"name":"Meng Cao","orcid":"0000-0002-2982-0841","position":6,"is_corresponding":false},{"id":1555573,"name":"Xi Zong","orcid":null,"position":7,"is_corresponding":false},{"id":274875,"name":"Min Ji","orcid":"0000-0002-8468-7772","position":8,"is_corresponding":false},{"id":299613,"name":"Jin Cai","orcid":"0000-0001-8826-1042","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Discovery of 4-aminoquinazoline—urea derivatives as Aurora kinase inhibitors with antiproliferative activity","abstract":"Two series of 20 novel 4-aminoquinazoline-urea derivatives have been designed and synthesized. The entire target compounds were investigated for their in vitro antiproliferative activity against six human cancer cell lines (K562, U937, A549, NCI-H661, HT29 and LoVo) using the MTT-based assay. Most compounds showed significant antiproliferative activities against four solid tumor cell lines, but no or poor activities against two leukemia cell lines. Furthermore, the target compounds were screened for Aurora A/B kinases inhibitory activity. Among them, 7c, 7d, 8c, and 8d are more potent against Aurora A kinase than ZM447439. Docking study of compounds 7d and ZM447439 revealed that they bound strongly to the ATP-binding sites of Aurora A and B. Thus, they may be promising lead compounds for the development of novel anti-tumor drug potentially via inhibiting Aurora kinases.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25270403","pmcid":null,"openalex_id":"https://openalex.org/W2111599174","authors":[],"funders":[{"funder_name":"Fundamental Research Funds","grant_id":"2242014R30019","title":null},{"funder_name":"Technology Supporting Program of Jiangsu province","grant_id":"BE2012657","title":null},{"funder_name":"National Basin Research Program of China","grant_id":"2011CB933503","title":null}],"total_grants":3,"fwci":0.8442,"citation_percentile":0.69878417,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":3},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://doi.org/10.7270/q279468g","host_type":"repository"},{"url":"https://doi.org/10.7270/q279468g","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0968089614006750?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968089614006750?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmc.2014.09.029","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25270403","host_type":"repository"}],"fields_of_study":["Microtubule and mitosis dynamics","Cancer-related Molecular Pathways","Protein Kinase Regulation and GTPase Signaling"],"mesh_terms":["Antineoplastic Agents","Benzamides","Binding Sites","Cell Survival","Drug Evaluation, Preclinical","Enzyme Activation","Humans","Quinazolines","Structure-Activity Relationship","Urea","Protein Structure, Tertiary","Cell Line, Tumor","Protein Kinase Inhibitors","Cell Proliferation","Molecular Docking Simulation","Aurora Kinase A","Aurora Kinase B"],"keywords":["Chemistry","Aurora kinase","Aurora A kinase","Aurora inhibitor","Kinase","Aurora B kinase","Docking (animal)","Cell culture","In vitro","Lead compound","Cell growth","IC50","K562 cells","Biochemistry","Cell","Cell cycle","Cell division","Biology","cancer cell","Quinazolines","Antiproliferative Activity","Docking Simulation","Zm447439"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:44:39.011493Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}