{"doi":"10.1016/j.bmc.2012.04.032","title":"Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors","abstract":null,"journal":"Bioorganic & Medicinal Chemistry","year":2012,"id":613926,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1581779,"name":"Feng’e Sun","orcid":null,"position":1,"is_corresponding":false},{"id":117238,"name":"Xuben Hou","orcid":"0000-0002-8346-9001","position":2,"is_corresponding":false},{"id":268593,"name":"Feng Wang","orcid":"0000-0002-1233-2745","position":3,"is_corresponding":false},{"id":822616,"name":"Fan Yi","orcid":"0000-0002-0053-8105","position":4,"is_corresponding":false},{"id":1581783,"name":"Wenfang Xu","orcid":null,"position":5,"is_corresponding":false},{"id":117239,"name":"Hao Fang","orcid":"0000-0002-2879-5146","position":6,"is_corresponding":false},{"id":409063,"name":"Peng Guan","orcid":"0000-0002-4207-0053","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors","abstract":"Histone deacetylase (HDAC) inhibitors have emerged as a new class of anticancer agents, targeting the biological processes including cell cycle, apoptosis and differentiation. In the present study, a series of 1,3,4-thiadiazole based hydroxamic acids were developed as potent HDAC inhibitors. Some of them showed good inhibitory activity in HDAC enzyme assay and potent growth inhibition in some tumor cell lines. Among them, compound 6i (IC(50) = 0.089 μM), exhibited better inhibitory effect compared with SAHA (IC(50) = 0.15 μM).","is_dataset_classified":null,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22579621","pmcid":null,"openalex_id":"https://openalex.org/W2081569115","authors":[],"funders":[],"total_grants":0,"fwci":1.7188,"citation_percentile":0.83946271,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":7},{"year":2015,"count":2},{"year":2016,"count":6},{"year":2017,"count":5},{"year":2018,"count":6},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":4},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0968089612003161?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968089612003161?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmc.2012.04.032","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22579621","host_type":"repository"}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Protein Degradation and Inhibitors","Click Chemistry and Applications","Antineoplastic Agents","Cell Line, Tumor","Cell Proliferation","Dose-Response Relationship, Drug","Drug Design","Drug Screening Assays, Antitumor","HeLa Cells","Histone Deacetylase Inhibitors","Histone Deacetylases","Humans","Hydroxamic Acids","K562 Cells","Models, Molecular","Molecular Structure","Structure-Activity Relationship","Thiadiazoles"],"mesh_terms":["Antineoplastic Agents","Dose-Response Relationship, Drug","Drug Screening Assays, Antitumor","HeLa Cells","Histone Deacetylases","Humans","Hydroxamic Acids","Models, Molecular","Structure-Activity Relationship","Thiadiazoles","Drug Design","Molecular Structure","K562 Cells","Cell Line, Tumor","Cell Proliferation","Histone Deacetylase Inhibitors","Hela Cells"],"keywords":["Histone deacetylase","Hydroxamic acid","Chemistry","IC50","Apoptosis","Enzyme","Biochemistry","Cell growth","Histone deacetylase inhibitor","Enzyme inhibitor","Histone deacetylase 5","HDAC11","HDAC1","Cell culture","Inhibitory postsynaptic potential","Pharmacology","Histone","In vitro","Stereochemistry","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T09:44:22.792009Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}