{"doi":"10.1016/j.bjps.2019.11.064","title":"Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants","abstract":"BACKGROUND: The risk of BIA-ALCL for patients with textured breast implants has been estimated between 1/2832 and 1/30,000 women. Existing studies estimating the numbers exposed and at risk, may have under reported cases, and/or lacked comprehensive follow-up. Our objective is to determine the risk of BIA-ALCL in a defined cohort of patients reconstructed with macro-textured breast implants and consistently followed long-term. METHODS: A prospective cohort study was conducted in patients who underwent breast reconstruction by a single surgeon at Memorial Sloan Kettering Cancer Center (MSKCC) from December 1992 to December 2017. Major events related to implants were prospectively recorded. We identified cases of BIA-ALCL by cross-checking clinical, pathology and external records data. Patients were followed until lymphoma occurrence or last follow-up. The primary outcomes were incidence rate per person-years and cumulative incidence. RESULTS: From 1992 to 2017, 3546 patients underwent 6023 breast reconstructions, mainly after breast cancer removal, or contralateral prophylactic mastectomy, using macro-textured surface expanders and implants. All reconstructions were performed by a single surgeon (PGC). Median follow-up was 8.1 years (range, 3 months - 30.9 years). Ten women, 1/354, developed ALCL after a median exposure of 11.5 years (range, 7.4-15.8 years). Overall risk of BIA-ALCL in our cohort is 1/355 women or 0.311 cases per 1000 person-years (95% CI 0.118 to 0.503). DISCUSSION: This study, the first to evaluate the risk of macro-textured breast implants from a prospective database with long term follow-up, demonstrates that the incidence rate of BIA-ALCL may be higher than previously reported. These results can help inform implant choice for women undergoing breast reconstruction.","journal":"Journal of Plastic Reconstructive & Aesthetic Surgery","year":2020,"id":50625,"datarank":0.7838620010569803,"base_score":5.225746673713202,"endowment":5.225746673713202,"self_citation_contribution":0.7838620010569803,"citation_network_contribution":0.0,"self_endowment_contribution":0.7838620010569803,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":185,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233575,"name":"Paola Ghione","orcid":"0000-0001-6986-7954","position":1,"is_corresponding":false},{"id":246202,"name":"Ai Ni","orcid":"0000-0003-3002-3556","position":2,"is_corresponding":false},{"id":249788,"name":"Qunying Hu","orcid":"0000-0002-6889-1757","position":3,"is_corresponding":false},{"id":249789,"name":"Nivetha Ganesan","orcid":"0009-0005-3491-8033","position":4,"is_corresponding":false},{"id":252739,"name":"Natasha Galasso","orcid":null,"position":5,"is_corresponding":false},{"id":34524,"name":"Ahmet Doǧan","orcid":"0000-0001-6576-5256","position":6,"is_corresponding":false},{"id":246207,"name":"Steven M. Horwitz","orcid":"0000-0002-6399-2006","position":7,"is_corresponding":false},{"id":252738,"name":"Peter G. Cordeiro","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:39:29.006085Z","pmid":"32008941","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}