{"doi":"10.1016/j.bj.2022.03.008","title":"Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses","abstract":null,"journal":"Biomedical Journal","year":2022,"id":628611,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1225062,"name":"Cui Yang","orcid":"0000-0003-1156-5325","position":1,"is_corresponding":false},{"id":1627602,"name":"Renaud Lesourne","orcid":"0000-0003-3816-7087","position":2,"is_corresponding":false},{"id":1627599,"name":"Suzanne Mélique","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses","abstract":"The activity of T cells is finely controlled by a set of negative regulators of T-cell antigen receptor (TCR)-mediated signaling. However, how those negative regulators are themselves controlled to prevent ineffective TCR-mediated responses remain poorly understood. Thymocyte-expressed molecule involved in selection (THEMIS) has been characterized over a decade ago as an important player of T cell development. Although the molecular function of THEMIS has long remained puzzling and subject to controversies, latest investigations suggest that THEMIS stimulates TCR-mediated signaling by repressing the tyrosine phosphatases SHP-1 and SHP-2 which exert regulatory function on T cell activation. Recent evidences also point to a role for THEMIS in peripheral T cells beyond its role on thymic selection. Here, we present an overview of the past research on THEMIS in the context of T cell development and peripheral T cell function and discuss the possible implication of THEMIS-based mechanisms on TCR-dependent and independent signaling outcomes.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35346866","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Agence Nationale de la Recherche","grant_id":"ANR-20-CE15-0002","title":"Modulation of immune checkpoint signaling in the context of central nervous system inflammation"}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S2319417022000373/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2319417022000373?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2319417022000373?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doaj.org/article/ad3bdb5d394f47cfa5987f9f32c3b1b0","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9250082","host_type":"repository"},{"url":"https://doi.org/10.1016/j.bj.2022.03.008","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/35346866","host_type":""},{"url":"http://dx.doi.org/10.1016/j.bj.2022.03.008","host_type":""},{"url":"https://hal.science/hal-04004393v1","host_type":""},{"url":"https://hal.science/hal-04004393v1/document","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Differentiation","Humans","Intracellular Signaling Peptides and Proteins","Lymphocyte Activation","Receptors, Antigen, T-Cell","Signal Transduction","T-Lymphocytes","Thymus Gland"],"mesh_terms":["Cell Differentiation","Humans","Intracellular Signaling Peptides and Proteins","Lymphocyte Activation","Receptors, Antigen, T-Cell","Signal Transduction","T-Lymphocytes","Thymus Gland"],"keywords":["[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology","T-Lymphocytes","T cell development","Adaptive immunity","T cells","Intracellular Signaling Peptides and Proteins","Receptors, Antigen, T-Cell","Cell Differentiation","Thymus Gland","Lymphocyte Activation","Signaling","Review Article: Special Edition","Humans","TCR","Signal Transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T14:17:07.716640Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}