{"doi":"10.1016/j.biotechadv.2015.02.011","title":"Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals","abstract":null,"journal":"Biotechnology Advances","year":2015,"id":604245,"datarank":0.8233406589235032,"base_score":5.488937726156687,"endowment":5.488937726156687,"self_citation_contribution":0.8233406589235032,"citation_network_contribution":0.0,"self_endowment_contribution":0.8233406589235032,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":241,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1550279,"name":"Florian David","orcid":null,"position":1,"is_corresponding":false},{"id":1550280,"name":"Brian Pfleger","orcid":null,"position":2,"is_corresponding":false},{"id":110749,"name":"Jens Nielsen","orcid":"0000-0002-9955-6003","position":3,"is_corresponding":false},{"id":1550278,"name":"David Jullesson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals","abstract":"Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.","is_dataset_classified":null,"base_score":5.488937726156687,"endowment":5.488937726156687,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25728067","pmcid":null,"openalex_id":"https://openalex.org/W2025902887","authors":[],"funders":[{"funder_name":"Novo Nordisk Fonden","grant_id":"NNF14SA0013603","title":null},{"funder_name":"NNF Center for Biosustainability","grant_id":"Yeast Cell Factories","title":null},{"funder_name":"Novo Nordisk Fonden","grant_id":"NNF10CC1016517","title":null},{"funder_name":"European Commission","grant_id":"247013","title":"Industrial Systems Biology of Yeast and A. oryzae"}],"total_grants":4,"fwci":10.7476,"citation_percentile":0.98932912,"influential_citations":0,"citation_trend":[{"year":2015,"count":8},{"year":2016,"count":31},{"year":2017,"count":17},{"year":2018,"count":22},{"year":2019,"count":37},{"year":2020,"count":28},{"year":2021,"count":28},{"year":2022,"count":19},{"year":2023,"count":13},{"year":2024,"count":14},{"year":2025,"count":16},{"year":2026,"count":8}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0734975015000361?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0734975015000361?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biotechadv.2015.02.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25728067","host_type":"repository"},{"url":"http://publications.lib.chalmers.se/publication/226535-impact-of-synthetic-biology-and-metabolic-engineering-on-industrial-production-of-fine-chemicals","host_type":"repository"},{"url":"https://orbit.dtu.dk/en/publications/65daa91c-cdeb-41e5-8e6c-2f81ccbed041","host_type":"repository"},{"url":"https://research.chalmers.se/en/publication/226535","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.biotechadv.2015.02.011","host_type":""},{"url":"http://dx.doi.org/10.1016/j.biotechadv.2015.02.011","host_type":""}],"fields_of_study":["Microbial Metabolic Engineering and Bioproduction","Biofuel production and bioconversion","Bacterial Genetics and Biotechnology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Escherichia coli","Industrial Microbiology","Metabolic Engineering","Saccharomyces cerevisiae","Synthetic Biology"],"mesh_terms":["Escherichia coli","Industrial Microbiology","Saccharomyces cerevisiae","Synthetic Biology","Metabolic Engineering"],"keywords":["Metabolic engineering","Synthetic biology","Biochemical engineering","Industrial microbiology","Automation","Production (economics)","Industrial production","Industrial biotechnology","Biotechnology","Systems biology","Chemical industry","Computer science","Manufacturing engineering","Biology","Computational biology","Engineering","Bacteria","Environmental engineering","Mechanical engineering","Saccharomyces cerevisiae","Escherichia Coli","Cell Factories"],"sdg_mappings":[{"sdg_number":12,"sdg_label":"12. 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