{"doi":"10.1016/j.bios.2022.114251","title":"Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes","abstract":null,"journal":"Biosensors and Bioelectronics","year":2022,"id":630822,"datarank":0.6573039952010823,"base_score":4.382026634673881,"endowment":4.382026634673881,"self_citation_contribution":0.6573039952010823,"citation_network_contribution":0.0,"self_endowment_contribution":0.6573039952010823,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1634466,"name":"Zhuping Shen","orcid":null,"position":1,"is_corresponding":false},{"id":1284990,"name":"Liping Deng","orcid":"0000-0001-8191-7731","position":2,"is_corresponding":false},{"id":413568,"name":"Guozhen Liu","orcid":"0000-0002-0556-6404","position":3,"is_corresponding":false},{"id":1634465,"name":"Shixian Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes","abstract":"Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au-S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1-50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05-15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35405503","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0956566322002913?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0956566322002913?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":["Biosensing Techniques","Carbon","Electrochemical Techniques","Electrodes","Glucose","Gold","Humans","Insulin","Limit of Detection","Metal Nanoparticles","Prediabetic State","Smartphone"],"mesh_terms":["Humans","Prediabetic State","Carbon","Gold","Insulin","Glucose","Biosensing Techniques","Electrodes","Metal Nanoparticles","Electrochemical Techniques","Limit of Detection","Smartphone"],"keywords":["Simultaneous detection","Glucose And Insulin","Electrochemical Aptasensors","Pre/diabetes","Smartphone Assisted Portable Biochip"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T22:13:53.087303Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}