{"doi":"10.1016/j.biopsych.2013.12.014","title":"Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice","abstract":null,"journal":"Biological Psychiatry","year":2014,"id":617281,"datarank":5.373143462173242,"base_score":5.10594547390058,"endowment":5.10594547390058,"self_citation_contribution":0.7658918210850871,"citation_network_contribution":4.607251641088155,"self_endowment_contribution":0.7658918210850871,"citer_contribution":4.607251641088155,"corpus_percentile":null,"corpus_rank":null,"citation_count":164,"citer_count":125,"citers_with_citation_signal":119,"citers_with_endowment":119,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519760,"name":"John W. Muschamp","orcid":null,"position":1,"is_corresponding":false},{"id":231775,"name":"Scott J. Russo","orcid":"0000-0002-6470-1805","position":2,"is_corresponding":false},{"id":196103,"name":"Eric J. Nestler","orcid":"0000-0002-7905-2000","position":3,"is_corresponding":false},{"id":55787,"name":"William A. Carlezon","orcid":"0000-0002-4162-3947","position":4,"is_corresponding":false},{"id":1591806,"name":"Rachel J. Donahue","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice","abstract":"<h4>Background</h4>Chronic social defeat stress (CSDS) produces persistent behavioral adaptations in mice. In many behavioral assays, it can be difficult to determine if these adaptations reflect core signs of depression. We designed studies to characterize the effects of CSDS on sensitivity to reward because anhedonia (reduced sensitivity to reward) is a defining characteristic of depressive disorders in humans. We also examined the effects of striatal ΔFosB overexpression and the N-methyl-D-aspartate receptor antagonist ketamine, both of which promote resilience, on CSDS-induced alterations in reward function and social interaction.<h4>Methods</h4>Intracranial self-stimulation (ICSS) was used to quantify CSDS-induced changes in reward function. Mice were implanted with lateral hypothalamic electrodes, and ICSS thresholds were measured after each of 10 daily CSDS sessions and during a 5-day recovery period. We also examined if acute intraperitoneal administration of ketamine (2.5-20 mg/kg) reverses CSDS-induced effects on reward or, in separate mice, social interaction.<h4>Results</h4>ICSS thresholds were increased by CSDS, indicating decreases in the rewarding impact of lateral hypothalamic stimulation (anhedonia). This effect was attenuated in mice overexpressing ∆FosB in striatum, consistent with pro-resilient actions of this transcription factor. High, but not low, doses of ketamine administered after completion of the CSDS regimen attenuated social avoidance in defeated mice, although this effect was transient. Ketamine did not block CSDS-induced anhedonia in the ICSS test.<h4>Conclusions</h4>This study found that CSDS triggers persistent anhedonia and confirms that ΔFosB overexpression produces stress resilience. The findings of this study also indicate that acute administration of ketamine fails to attenuate CSDS-induced anhedonia despite reducing other depression-related behavioral abnormalities.","is_dataset_classified":null,"base_score":5.10594547390058,"endowment":5.10594547390058,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24495460","pmcid":"PMC4087093","openalex_id":"https://openalex.org/W2062102986","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH063266","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"P50 MH096890","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R00 DA031767","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH051399","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH090264","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01MH51399","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R37 DA007359","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH063266","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH090264","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"T32 MH020017","title":null}],"total_grants":10,"fwci":7.4609,"citation_percentile":0.98574443,"influential_citations":0,"citation_trend":[{"year":2014,"count":13},{"year":2015,"count":15},{"year":2016,"count":14},{"year":2017,"count":17},{"year":2018,"count":18},{"year":2019,"count":18},{"year":2020,"count":15},{"year":2021,"count":8},{"year":2022,"count":13},{"year":2023,"count":11},{"year":2024,"count":9},{"year":2025,"count":8},{"year":2026,"count":5}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087093","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087093","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0006322314000043?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006322314000043?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biopsych.2013.12.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24495460","host_type":"repository"}],"fields_of_study":["Neurotransmitter Receptor Influence on Behavior","Treatment of Major Depression","Tryptophan and brain disorders","Anhedonia","Animals","Antidepressive Agents","Corpus Striatum","Electric Stimulation","Hypothalamus","Ketamine","Male","Mice","Mice, Inbred C57BL","Proto-Oncogene Proteins c-fos","Reward","Self Stimulation","Social Behavior","Stress, Psychological"],"mesh_terms":["Animals","Antidepressive Agents","Corpus Striatum","Electric Stimulation","Hypothalamus","Ketamine","Male","Mice, Inbred C57BL","Reward","Self Stimulation","Social Behavior","Stress, Psychological","Proto-Oncogene Proteins c-fos","Mice","Anhedonia"],"keywords":["Anhedonia","Social defeat","FOSB","Brain stimulation reward","Ketamine","Nucleus accumbens","Striatum","Neuroscience","Stimulation","Psychology","Dopamine","Medicine","Pharmacology","Endocrinology","Internal medicine","Biology","Transcription factor","Stress","Antidepressant","Social Interaction","Defeat","Intracranial Self-stimulation (Icss)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T01:18:42.616204Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}