{"doi":"10.1016/j.biopsych.2005.09.021","title":"Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients","abstract":null,"journal":"Biological Psychiatry","year":2006,"id":635089,"datarank":0.7465100613630863,"base_score":4.976733742420574,"endowment":4.976733742420574,"self_citation_contribution":0.7465100613630863,"citation_network_contribution":0.0,"self_endowment_contribution":0.7465100613630863,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":144,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398316,"name":"Marek Kubicki","orcid":"0000-0002-3989-8212","position":1,"is_corresponding":false},{"id":351559,"name":"Paul G. Nestor","orcid":"0000-0003-4890-8950","position":2,"is_corresponding":false},{"id":376748,"name":"Dean F. Salisbury","orcid":"0000-0002-8533-0599","position":3,"is_corresponding":false},{"id":1647494,"name":"Hae-Jeong Park","orcid":null,"position":4,"is_corresponding":false},{"id":432466,"name":"James J. Levitt","orcid":"0000-0001-9733-870X","position":5,"is_corresponding":false},{"id":1647495,"name":"Sophie Woolston","orcid":null,"position":6,"is_corresponding":false},{"id":1647496,"name":"Melissa Frumin","orcid":null,"position":7,"is_corresponding":false},{"id":411189,"name":"Margaret Niznikiewicz","orcid":"0000-0003-3191-2005","position":8,"is_corresponding":false},{"id":1647497,"name":"Carl-Fredrik Westin","orcid":null,"position":9,"is_corresponding":false},{"id":494406,"name":"Stephan E. Maier","orcid":"0000-0003-0646-3893","position":10,"is_corresponding":false},{"id":62399,"name":"Robert W. McCarley","orcid":"0000-0001-5705-7495","position":11,"is_corresponding":false},{"id":274933,"name":"Martha E. Shenton","orcid":"0000-0003-4235-7879","position":12,"is_corresponding":false},{"id":1647491,"name":"Noriomi Kuroki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients","abstract":"<h4>Background</h4>The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia.<h4>Methods</h4>Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (D(m)), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume.<h4>Results</h4>FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. D(m) was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean D(m) and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes.<h4>Conclusions</h4>These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.","is_dataset_classified":null,"base_score":4.976733742420574,"endowment":4.976733742420574,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16406249","pmcid":"PMC2768597","openalex_id":"https://openalex.org/W1966083344","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"K02 MH 01110","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R03 MH068464","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R03 MH068464-01","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH 50747","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"K02 MH001110","title":null},{"funder_name":"NIBIB NIH HHS","grant_id":"U54 EB005149","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH 40799","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH040799","title":null}],"total_grants":8,"fwci":10.8169,"citation_percentile":0.98902602,"influential_citations":0,"citation_trend":[{"year":2012,"count":11},{"year":2013,"count":7},{"year":2014,"count":10},{"year":2015,"count":8},{"year":2016,"count":9},{"year":2017,"count":3},{"year":2018,"count":4},{"year":2019,"count":6},{"year":2020,"count":4},{"year":2021,"count":7},{"year":2023,"count":5},{"year":2026,"count":2}],"oa_status":"bronze","license":"cc-by","oa_locations":[{"url":"http://www.biologicalpsychiatryjournal.com/article/S0006322305013673/pdf","host_type":"journal"},{"url":"http://www.biologicalpsychiatryjournal.com/article/S0006322305013673/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006322305013673?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006322305013673?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biopsych.2005.09.021","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16406249","host_type":"repository"},{"url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/109098","host_type":"repository"},{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:28566444","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2768597","host_type":"repository"}],"fields_of_study":["Advanced Neuroimaging Techniques and Applications","Schizophrenia research and treatment","Neurogenesis and neuroplasticity mechanisms","Adult","Anisotropy","Brain Mapping","Diffusion Magnetic Resonance Imaging","Fornix, Brain","Functional Laterality","Hippocampus","Humans","Image Processing, Computer-Assisted","Male","Middle Aged","Schizophrenia","Statistics, Nonparametric"],"mesh_terms":["Adult","Brain Mapping","Hippocampus","Humans","Image Processing, Computer-Assisted","Functional Laterality","Male","Middle Aged","Schizophrenia","Anisotropy","Statistics, Nonparametric","Fornix, Brain","Diffusion Magnetic Resonance Imaging"],"keywords":["Fornix","Hippocampus","Hippocampal formation","Diffusion MRI","Schizophrenia (object-oriented programming)","Neuroscience","Fractional anisotropy","Psychology","Magnetic resonance imaging","White matter","Medicine","Psychiatry","Radiology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:37:56.170443Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}