{"doi":"10.1016/j.biopha.2020.110652","title":"Small molecule compounds promote the proliferation of chondrocytes and chondrogenic differentiation of stem cells in cartilage tissue engineering","abstract":null,"journal":"Biomedicine & Pharmacotherapy","year":2020,"id":620724,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1602499,"name":"Bingzhang Liu","orcid":null,"position":1,"is_corresponding":false},{"id":571442,"name":"Kang Chen","orcid":"0000-0002-6507-9464","position":2,"is_corresponding":false},{"id":1602500,"name":"Yingyue Lou","orcid":null,"position":3,"is_corresponding":false},{"id":990906,"name":"Yuhan Jiang","orcid":"0000-0002-5224-6294","position":4,"is_corresponding":false},{"id":185371,"name":"Duo Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":657183,"name":"Tian Li","orcid":"0000-0001-7810-7711","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Small molecule compounds promote the proliferation of chondrocytes and chondrogenic differentiation of stem cells in cartilage tissue engineering","abstract":"The application of tissue engineering to generate cartilage is limited because of low proliferative ability and unstable phenotype of chondrocytes. The sources of cartilage seed cells are mainly chondrocytes and stem cells. A variety of methods have been used to obtain large numbers of chondrocytes, including increasing chondrocyte proliferation and stem cell chondrogenic differentiation via cytokines, genes, and proteins. Natural or synthetic small molecule compounds can provide a simple and effective method to promote chondrocyte proliferation, maintain a stable chondrocyte phenotype, and promote stem cell chondrogenic differentiation. Therefore, the study of small molecule compounds is of great importance for cartilage tissue engineering. Herein, we review a series of small molecule compounds and their mechanisms that can promote chondrocyte proliferation, maintain chondrocyte phenotype, or induce stem cell chondrogenesis. The studies in this field represent significant contributions to the research in cartilage tissue engineering and regenerative medicine.","is_dataset_classified":null,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32942151","pmcid":null,"openalex_id":"https://openalex.org/W3085038063","authors":[],"funders":[{"funder_name":"Chinese Academy of Medical Sciences","grant_id":"CAMS-2017-I2M-1-007","title":null}],"total_grants":1,"fwci":3.9432,"citation_percentile":0.95016556,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":14},{"year":2023,"count":8},{"year":2024,"count":9},{"year":2025,"count":16},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0753332220308453/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0753332220308453/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0753332220308453?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0753332220308453?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biopha.2020.110652","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32942151","host_type":"repository"},{"url":"https://doaj.org/article/cac01a1360a44b1c82a70d5b111e89f5","host_type":"repository"}],"fields_of_study":["Osteoarthritis Treatment and Mechanisms","Silk-based biomaterials and applications","Chemical Synthesis and Analysis","Animals","Ascorbic Acid","Cartilage, Articular","Cell Differentiation","Chondrocytes","Chondrogenesis","Glucosamine","Humans","Regenerative Medicine","Stem Cells","Tissue Engineering"],"mesh_terms":["Animals","Ascorbic Acid","Cartilage, Articular","Cell Differentiation","Glucosamine","Humans","Stem Cells","Chondrocytes","Chondrogenesis","Tissue Engineering","Regenerative Medicine"],"keywords":["Chondrogenesis","Chondrocyte","Cell biology","Cartilage","Stem cell","Tissue engineering","Cellular differentiation","Chemistry","Biology","Anatomy","Biochemistry","Gene","Genetics","Chondrocyte proliferation","Small molecule compounds","Stem cells"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.20430692.v1","title":"Additional file 1 of Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20430692","title":"Additional file 1 of Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20430695.v1","title":"Additional file 2 of Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20430695","title":"Additional file 2 of Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26565977.v1","title":"Additional file 1 of All-in-one smart dressing for simultaneous angiogenesis and neural regeneration","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26565977","title":"Additional file 1 of All-in-one smart dressing for simultaneous angiogenesis and neural regeneration","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T11:58:03.531403Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}