{"doi":"10.1016/j.biopha.2014.12.008","title":"The role of CCL20/CCR6 axis in recruiting Treg cells to tumor sites of NSCLC patients","abstract":null,"journal":"Biomedicine & Pharmacotherapy","year":2015,"id":660159,"datarank":0.635115975689589,"base_score":4.23410650459726,"endowment":4.23410650459726,"self_citation_contribution":0.635115975689589,"citation_network_contribution":0.0,"self_endowment_contribution":0.635115975689589,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1090122,"name":"Yu Qi","orcid":null,"position":1,"is_corresponding":false},{"id":1723330,"name":"Xiang-nan Li","orcid":null,"position":2,"is_corresponding":false},{"id":588297,"name":"Yang Yang","orcid":"0000-0001-8572-5155","position":3,"is_corresponding":false},{"id":1723332,"name":"Dong-lei Liu","orcid":null,"position":4,"is_corresponding":false},{"id":515290,"name":"Jia Zhao","orcid":"0000-0001-8962-8029","position":5,"is_corresponding":false},{"id":1723335,"name":"Deng-yan Zhu","orcid":null,"position":6,"is_corresponding":false},{"id":1256701,"name":"Kai Wu","orcid":"0000-0003-4467-1597","position":7,"is_corresponding":false},{"id":1723336,"name":"Xu-dong Zhou","orcid":null,"position":8,"is_corresponding":false},{"id":1643394,"name":"Song Zhao","orcid":null,"position":9,"is_corresponding":false},{"id":117719,"name":"Chun-yang Zhang","orcid":"0000-0002-8010-1981","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of CCL20/CCR6 axis in recruiting Treg cells to tumor sites of NSCLC patients","abstract":"Inflammatory chemokine CCL20 and its receptor CCR6 have been reported to correlate with colorectal cancer patients' metastasis. However, the role of CCL20 in patients with NSCLC is not well defined. In this study, we detected the expression of CCL20 in tumor samples and corresponding adjacent ones (n=71) from patients with NSCLC using RT-PCR and observed that CCL20 showed higher expression in tumor samples (0.28±0.17) than in adjacent ones (0.20±0.13) (n=71, P=0.0056), which was also verified in protein level using IHC. Analysis results showed that CCL20 expression was positively associated with CD4 (n=80, P=0.0046), Foxp3 (n=80, P=0.0020) and IL-10 (n=61, P=0.0003) in tumor samples. And the flow data showed that Treg cells accumulated in TIL (MFI: 961±760) compared with PBMC (MFI: 683±460) (n=40, P=0.0046); and the percentage of CCR6 - the sole receptor of CCL20 - on Treg cells was higher in TIL (MFI: 1311±1268) than in PBMC (MFI: 976±780) (n=40, P=0.0219). It was interesting to find that the expression of CCL20 in tumor sites was almost 1.5-fold higher in samples from high-stage patients (III-IV stage, 0.34±0.17) compared with those from low-stage patients (I-II stage, 0.22±0.11) (P=0.0056). Furthermore, the higher expression of CCL20 was associated with a lower overall survival (P=0.0198). The IHC data showed that tumor cells were the main source of CCL20, and after treated cell line A549 with docetaxel, we found that the secretion of CCL20 was decreased heavily (n=3, P=0.0046). Our results demonstrated that CCL20 cooperated with CCR6 could recruit Treg cells to tumor sites, and chemotherapy medicine docetaxel could decrease the expression of CCL20.","is_dataset_classified":null,"base_score":4.23410650459726,"endowment":4.23410650459726,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25661365","pmcid":null,"openalex_id":"https://openalex.org/W2007663061","authors":[],"funders":[{"funder_name":"Henan Province High Education Territory Science and Technology Innovation Team","grant_id":"13IRTSTHN011","title":null}],"total_grants":1,"fwci":0.9663,"citation_percentile":0.74592699,"influential_citations":0,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":13},{"year":2021,"count":12},{"year":2022,"count":3},{"year":2023,"count":8},{"year":2024,"count":5},{"year":2025,"count":9},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0753332214002030?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0753332214002030?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biopha.2014.12.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25661365","host_type":"repository"}],"fields_of_study":["Chemokine receptors and signaling","Immunotherapy and Immune Responses","Immune Cell Function and Interaction"],"mesh_terms":["Docetaxel","Aged","Carcinoma, Non-Small-Cell Lung","Female","Humans","Lung Neoplasms","Male","Middle Aged","Signal Transduction","Gene Expression Regulation, Neoplastic","Lymphocytes, Tumor-Infiltrating","Disease Progression","Taxoids","Cell Line, Tumor","T-Lymphocytes, Regulatory","Receptors, CCR6","Chemokine CCL20"],"keywords":["CCL20","C-C chemokine receptor type 6","Chemokine","FOXP3","Metastasis","Stage (stratigraphy)","Immunohistochemistry","Cancer research","Medicine","Receptor","Cancer","Biology","Internal medicine","Chemokine receptor","Immunology","Immune system","NSCLC","Docetaxel"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T08:34:39.173801Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}