{"doi":"10.1016/j.biopha.2011.09.016","title":"The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients","abstract":null,"journal":"Biomedicine & Pharmacotherapy","year":2012,"id":650145,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":200840,"name":"Djordje Jevtovic","orcid":null,"position":1,"is_corresponding":false},{"id":200839,"name":"Gordana Dragovic","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients","abstract":"Hyperlactatemia and lactic acidosis (LA) are among the most dangerous and life-threatening side effect that occurs during therapy with some nucleoside reverse transcriptase inhibitors (NRTIs), mainly didanosine (ddI) and stavudine (d4T), also known as d-drugs. Therefore, we performed a prospective, follow-up study and aimed to examine the incidence rates (IR) and rate ratios (RR) of hyperlactatemia and LA for each NRTI. Three hundred and ninety-six HIV-patients were included in final analysis comprising 783.8 person-years of follow-up. Between 1st January 2000 and 1st January 2008, 19 cases of hyperlactatemia and 15 cases of LA were recorded. Between regimens with the significant impact for developing hyperlactatemia and LA the lowest IR was for didanosine (IR=2.87 per 100 person-years, 95%CI=0.45-9.25 and IR=4.31 per 100 person-years, 95%CI=1.07-13.91, respectively), and the highest for didanosine+stavudine (IR=10.17 per 100 person-years, 95%CI=1.02-19.76 and IR=7.39 per 100 person-years, 95%CI=1.02-13.05, respectively). Compared to didanosine alone the RR of hyperlactatemia was 2.67 (95%CI=1.11-12.52) for stavudine, and 4.06 (95%CI=1.31-15.48) for didanosine+stavudine. The RR of LA was 3.12 (95%CI=1.13-10.65) for stavudine, and 5.13 (95%CI=1.54-13.37) for didanosine+stavudine in comparison with didanosine alone. Other risk factors for AP were CD4 cell count less than 200 cells/mm³ and female sex. Our results suggest that the use of stavudine alone or in combination with didanosine should not be used as first-line therapy, especially in patients with CD4 cell count less than 200 cells/mm³ and females if other treatment options are available.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22658063","pmcid":null,"openalex_id":"https://openalex.org/W2041480391","authors":[],"funders":[],"total_grants":0,"fwci":2.5317,"citation_percentile":0.88765735,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":7},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0753332212000534?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0753332212000534?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biopha.2011.09.016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22658063","host_type":"repository"}],"fields_of_study":["HIV-related health complications and treatments","HIV/AIDS drug development and treatment","Pneumocystis jirovecii pneumonia detection and treatment","Acidosis, Lactic","Acquired Immunodeficiency Syndrome","Adult","CD4 Lymphocyte Count","Didanosine","Drug Therapy, Combination","Female","Follow-Up Studies","HIV Infections","Humans","Incidence","Lactic Acid","Male","Middle Aged","Prospective Studies","Reverse Transcriptase Inhibitors","Risk Factors","Sex Factors","Stavudine"],"mesh_terms":["Acidosis, Lactic","Acquired Immunodeficiency Syndrome","Adult","Drug Therapy, Combination","Female","Follow-Up Studies","Humans","Male","Middle Aged","Prospective Studies","Risk Factors","Sex Factors","HIV Infections","Incidence","Didanosine","Stavudine","CD4 Lymphocyte Count","Reverse Transcriptase Inhibitors","Lactic Acid"],"keywords":["Stavudine","Didanosine","Hyperlactatemia","Medicine","Reverse-transcriptase inhibitor","Lactic acidosis","Mitochondrial toxicity","Internal medicine","Gastroenterology","Human immunodeficiency virus (HIV)","Zidovudine","Virology","Sida","Viral disease","Toxicity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:55:32.363635Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}