{"doi":"10.1016/j.bioorg.2023.106586","title":"Discovery of potent natural product higenamine derivatives as novel Anti-Fusobacterium nucleatum agents","abstract":null,"journal":"Bioorganic Chemistry","year":2023,"id":605566,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1198846,"name":"Qingwei Bu","orcid":"0000-0002-3137-4799","position":1,"is_corresponding":false},{"id":1554171,"name":"Xuexin Bai","orcid":null,"position":2,"is_corresponding":false},{"id":1554172,"name":"Yahui Huang","orcid":null,"position":3,"is_corresponding":false},{"id":953079,"name":"Fangfang Wang","orcid":"0000-0002-5441-4490","position":4,"is_corresponding":false},{"id":86906,"name":"Jie Hong","orcid":"0000-0001-9579-0794","position":5,"is_corresponding":false},{"id":86908,"name":"Jing-Yuan Fang","orcid":null,"position":6,"is_corresponding":false},{"id":1554173,"name":"Shanchao Wu","orcid":"0000-0001-7632-2776","position":7,"is_corresponding":false},{"id":110985,"name":"Chunquan Sheng","orcid":"0000-0001-9489-804X","position":8,"is_corresponding":false},{"id":1554170,"name":"Sijia Su","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Discovery of potent natural product higenamine derivatives as novel Anti-Fusobacterium nucleatum agents","abstract":"Fusobacterium nucleatum (F. nucleatum) is closely associated with the occurrence and development of colorectal cancer (CRC). Discovery of specific antibacterial agents against F. nucleatum was urgent for the prevention and treatment of CRC. We screened a natural product library and successfully identified higenamine as an antibacterial hit against F. nucleatum. Further hit optimizations led to the discovery of new higenamine derivatives with improved anti-F. nucleatum activity. Among them, compound 7c showed potent antibacterial activity against F. nucleatum (MIC<sub>50</sub> = 0.005 μM) with good selectivity toward intestinal bacteria and normal cells. It significantly inhibited the migration of CRC cells induced by F. nucleatum. Mechanism study revealed that compound 7c impaired the integrity of biofilm and cell wall, which represents a good starting point for the development of novel anti-F. nucleatum agents.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37178651","pmcid":null,"openalex_id":"https://openalex.org/W4367837572","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2020YFA0509200","title":null},{"funder_name":"Shanghai Rising-Star Program","grant_id":"22QA1411300","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22077138","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81725020","title":null}],"total_grants":4,"fwci":0.5601,"citation_percentile":0.60857944,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":4}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S004520682300247X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S004520682300247X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bioorg.2023.106586","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37178651","host_type":"repository"}],"fields_of_study":["Gut microbiota and health","Clostridium difficile and Clostridium perfringens research","Berberine and alkaloids research","Humans","Colorectal Neoplasms","Fusobacterium nucleatum","Anti-Bacterial Agents","Alkaloids","Tetrahydroisoquinolines"],"mesh_terms":["Alkaloids","Anti-Bacterial Agents","Humans","Colorectal Neoplasms","Fusobacterium nucleatum","Tetrahydroisoquinolines"],"keywords":["Fusobacterium nucleatum","Chemistry","Natural product","Bacteria","Microbiology","Antibacterial activity","Biofilm","Fusobacterium","Colorectal cancer","Biochemistry","Cancer","Biology","Higenamine","Migration Inhibition"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T02:44:14.601883Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}