{"doi":"10.1016/j.bioorg.2018.10.072","title":"A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation","abstract":null,"journal":"Bioorganic Chemistry","year":2019,"id":606411,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311224,"name":"Ye Yuan","orcid":"0000-0002-8339-0504","position":1,"is_corresponding":false},{"id":1556787,"name":"Ruining Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":79648,"name":"Yanhui Song","orcid":"0000-0003-2456-222X","position":3,"is_corresponding":false},{"id":1556788,"name":"Tianzhuo Sui","orcid":null,"position":4,"is_corresponding":false},{"id":388361,"name":"Jiaqi Wang","orcid":"0009-0005-4951-0970","position":5,"is_corresponding":false},{"id":1556789,"name":"Chonghan Wang","orcid":null,"position":6,"is_corresponding":false},{"id":1464130,"name":"Yujia Chen","orcid":"0009-0008-7165-6134","position":7,"is_corresponding":false},{"id":651448,"name":"Shuwen Guan","orcid":"0000-0001-8235-933X","position":8,"is_corresponding":false},{"id":592228,"name":"Liping Wang","orcid":"0000-0002-3458-4513","position":9,"is_corresponding":false},{"id":1068546,"name":"Jia Xu","orcid":"0000-0002-0019-9502","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation","abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative brain disease and is the most common cause of dementia in the elderly. The main hallmark of AD is the deposition of insoluble amyloid (Aβ) outside the neuron, leading to amyloid plaques and neurofibrillary tangles in the brain. Deuterohemin-Ala-His-Thr-Val-Glu-Lys (DhHP-6), a novel porphyrin-peptide, has both microperoxidase activity and cell permeability. In the present study, DhHP-6 efficiently inhibited the aggregation of Aβ and reduced the β-sheet percentage of Aβ from 89.1% to 78.3%. DhHP-6 has a stronger affinity (K<sub>D</sub> = 100 ± 12 μM) for binding with Aβ at Phe<sup>4</sup>, Arg<sup>5</sup>, Val<sup>18</sup>, Glu<sup>11</sup> and Glu<sup>22</sup>. In addition, DhHP-6 (100 μM) significantly prolonged lifespan, alleviated paralysis and reduced Aβ plaque formation in the Aβ<sub>1-42</sub> transgenic Caenorhabditis elegans CL4176 model of AD. Our results demonstrate that DhHP-6 is a potential drug candidate that efficiently protects a transgenic C. elegans model of Alzheimer's disease by inhibiting Aβ aggregation.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30428413","pmcid":null,"openalex_id":"https://openalex.org/W2898704576","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China, China","grant_id":"31401086","title":null},{"funder_name":"Jilin Province Science and Technology Development Program, China","grant_id":"20150520157JH","title":null},{"funder_name":"China Postdoctoral Science Foundation Grant, China","grant_id":"2015M581398","title":null}],"total_grants":3,"fwci":1.0076,"citation_percentile":0.75756453,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0045206818309568?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0045206818309568?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bioorg.2018.10.072","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30428413","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Cholinesterase and Neurodegenerative Diseases","Genetics, Aging, and Longevity in Model Organisms","Alzheimer Disease","Amyloid beta-Peptides","Animals","Animals, Genetically Modified","Biomimetic Materials","Caenorhabditis elegans","Free Radical Scavengers","Hemin","Longevity","Molecular Docking Simulation","Oligopeptides","Paralysis","Peptide Fragments","Peroxidases","Protein Conformation, alpha-Helical","Protein Conformation, beta-Strand","Protein Multimerization"],"mesh_terms":["Protein Conformation, alpha-Helical","Protein Conformation, beta-Strand","Alzheimer Disease","Animals","Hemin","Longevity","Oligopeptides","Paralysis","Peptide Fragments","Peroxidases","Free Radical Scavengers","Amyloid beta-Peptides","Caenorhabditis elegans","Animals, Genetically Modified","Biomimetic Materials","Protein Multimerization","Molecular Docking Simulation"],"keywords":["Caenorhabditis elegans","Transgene","Chemistry","Genetically modified mouse","Peptide","Cell biology","Alzheimer's disease","Amyloid (mycology)","Neuroscience","Disease","Biochemistry","Internal medicine","Biology","Medicine","Gene","Alzheimer’s disease","Amyloid Β","Deuterohemin Peptide"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:30:00.214340Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}