{"doi":"10.1016/j.biochi.2016.12.006","title":"Brown fat thermogenesis: Stability of developmental programming and transient effects of temperature and gut microbiota in adults","abstract":null,"journal":"Biochimie","year":2017,"id":47339,"datarank":0.7706255146069207,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.337069750922496,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.337069750922496,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":17,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":218819,"name":"Agnieszka Chabowska-Kita","orcid":null,"position":1,"is_corresponding":false},{"id":218820,"name":"Leslie Paul Kozak","orcid":null,"position":2,"is_corresponding":false},{"id":218818,"name":"Marika Ziętak","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Brown fat thermogenesis: Stability of developmental programming and transient effects of temperature and gut microbiota in adults","abstract":"Evidence from animal studies continues to document the effectiveness of brown fat based thermogenesis in stimulating energy expenditure to reduce obesity. Evidence shows that the number of brown adipocytes in white fat is determined by developmental mechanisms, not the environment. The large variability in the capacity for brown fat thermogenesis comes from genetic variability in developmental mechanisms extent in the animal. This genetic variability ultimately drives the capacity for induction of the brown adipocyte phenotype in response to environmental signals in adult animals. We highlight recent studies that suggest a role for gut microbiota in the regulation of brown fat thermogenesis that is based, in part, upon the observation that bile acids can effectively induce thermogenesis by interscapular brown fat at thermoneutrality.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27965179","pmcid":null,"openalex_id":"https://openalex.org/W2560315139","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"FP7-REGPOT-2010-1-264103","title":null},{"funder_name":"Fundacja na rzecz Nauki Polskiej","grant_id":"WELCOME/2010-4/3","title":null}],"total_grants":2,"fwci":1.4955,"citation_percentile":0.82643486,"influential_citations":0,"citation_trend":[{"year":2018,"count":5},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0300908416303789?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0300908416303789?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biochi.2016.12.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27965179","host_type":"repository"}],"fields_of_study":["Adipose Tissue and Metabolism","Diet and metabolism studies","Adipokines, Inflammation, and Metabolic Diseases","Biology","Medicine","Environmental Science","Adipocytes, Brown","Adipocytes, White","Adult","Animals","Bile Acids and Salts","Cell Count","Energy Metabolism","Gastrointestinal Microbiome","Gene Expression Regulation","Humans","Mice","Obesity","Receptors, Adrenergic","Signal Transduction","Temperature","Thermogenesis","Uncoupling Protein 1"],"mesh_terms":["Gastrointestinal Microbiome","Uncoupling Protein 1","Adult","Animals","Bile Acids and Salts","Cell Count","Energy Metabolism","Gene Expression Regulation","Humans","Obesity","Receptors, Adrenergic","Temperature","Signal Transduction","Thermogenesis","Mice","Adipocytes, Brown","Adipocytes, White"],"keywords":["Thermogenesis","Brown adipose tissue","Biology","Thermoregulation","Endocrinology","Internal medicine","Obesity","Medicine","Genetic variability","Bile acids","postnatal development","Gut Microbiota","Brown Adipocytes","Thermoneutrality","Interscapular Brown Fat","Inguinal White Fat","Reduced Ambient Temperature"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T15:50:49.534715Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}