{"doi":"10.1016/j.biocel.2021.105951","title":"The relevance of mitochondrial morphology for human disease","abstract":null,"journal":"The International Journal of Biochemistry & Cell Biology","year":2021,"id":657544,"datarank":1.4242888502942788,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.8316022925070644,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.8316022925070644,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":46,"citers_with_citation_signal":37,"citers_with_endowment":37,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":577590,"name":"Ruchika Anand","orcid":"0000-0001-7337-6007","position":1,"is_corresponding":false},{"id":577591,"name":"Andreas S. Reichert","orcid":"0000-0001-9340-3113","position":2,"is_corresponding":false},{"id":301284,"name":"Felix Distelmaier","orcid":"0000-0003-4304-7848","position":3,"is_corresponding":false},{"id":1716506,"name":"Tharsini Navaratnarajah","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The relevance of mitochondrial morphology for human disease","abstract":"Mitochondria are highly dynamic organelles, which undergo frequent structural and metabolic changes to fulfil cellular demands. To facilitate these processes several proteins are required to regulate mitochondrial shape and interorganellar communication. These proteins include the classical mitochondrial fusion (MFN1, MFN2, and OPA1) and fission proteins (DRP1, MFF, FIS1, etc.) as well as several other proteins that are directly or indirectly involved in these processes (e.g. YME1L, OMA1, INF2, GDAP1, MIC13, etc.). During the last two decades, inherited genetic defects in mitochondrial fusion and fission proteins have emerged as an important class of neurodegenerative human diseases with variable onset ranging from infancy to adulthood. So far, no causal treatment strategies are available for these disorders. In this review, we provide an overview about the current knowledge on mitochondrial dynamics under physiological conditions. Moreover, we describe human diseases, which are associated with genetic defects in these pathways.","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33610749","pmcid":null,"openalex_id":"https://openalex.org/W3129843421","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"German Research Foundation","grant_id":"","title":null}],"total_grants":2,"fwci":2.739,"citation_percentile":0.91710518,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":11},{"year":2023,"count":12},{"year":2024,"count":13},{"year":2025,"count":10},{"year":2026,"count":4}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1357272521000352?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1357272521000352?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.biocel.2021.105951","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33610749","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.biocel.2021.105951","host_type":""}],"fields_of_study":["Mitochondrial Function and Pathology","Metabolism and Genetic Disorders","ATP Synthase and ATPases Research","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Humans","Microtubule-Associated Proteins","Mitochondria","Neurodegenerative Diseases","GTP Phosphohydrolases","Mitochondrial Proteins","Mitochondrial Dynamics"],"keywords":["MFN2","FIS1","mitochondrial fusion","MFN1","Mitochondrion","Biology","Mitochondrial fission","Cell biology","Computational biology","HSPA9","Genetics","Mitochondrial DNA","Gene","Alzheimer’s disease","Parkinson’s Disease","Cristae","Mitochondrial Dynamics","Oxphos","Mitochondriopathy","Mitochondrial Proteins","Animals","Humans","Neurodegenerative Diseases","Microtubule-Associated Proteins","GTP Phosphohydrolases","Mitochondria"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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