{"doi":"10.1016/j.biocel.2007.05.004","title":"Nuclear factor-κB1: Regulation and function","abstract":null,"journal":"The International Journal of Biochemistry & Cell Biology","year":2008,"id":609997,"datarank":0.779774554689874,"base_score":5.198497031265826,"endowment":5.198497031265826,"self_citation_contribution":0.779774554689874,"citation_network_contribution":0.0,"self_endowment_contribution":0.779774554689874,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":180,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":569127,"name":"Fiona Oakley","orcid":"0000-0001-8692-1836","position":1,"is_corresponding":false},{"id":1568108,"name":"Silvia Gaspar Pereira","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nuclear factor-κB1: Regulation and function","abstract":"The transcription factor NF-kappaB is a critical regulator of many cellular processes including cell survival and inflammation. NF-kappaB functions as a hetero- or homo-dimer which can be formed from five NF-kappaB subunits, NF-kappaB1 (p50 and its precursor p105), NF-kappaB2 (p52 and its precursor p100), RelA (p65), RelB and c-Rel. The most studied dimer is p50:p65, which is activated by the classical pathway and usually promotes gene expression. Activation of p50:p65 is linked with cell survival and promoting inflammation. This review provides a detailed overview of the structure, synthesis and function of the lesser characterised NF-kappaB subunit; NF-kappaB1 (p105 and p50). The diverse interactions of NF-kappaB1 with co-activators, co-repressors and other signaling networks that influence NF-kappaB1 gene expression are discussed. Finally the anti-inflammatory actions of NF-kappaB1 signaling will be assessed and the crucial need to design novel therapeutic drugs which exploit and amplify the anti-inflammatory actions of p50 will be explored.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17693123","pmcid":null,"openalex_id":"https://openalex.org/W17693123","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Medical Research Council","grant_id":"","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.00242014,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1357272507001501?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1357272507001501?httpAccept=text/plain","host_type":"publisher"},{"url":"https://ci.nii.ac.jp/naid/110003672162","host_type":"journal"}],"fields_of_study":["NF-κB Signaling Pathways","Healthcare and Venom Research","Ginger and Zingiberaceae research"],"mesh_terms":["Animals","Humans","Anti-Inflammatory Agents","Signal Transduction","Transcription, Genetic","Dimerization","NF-kappa B p50 Subunit"],"keywords":["Computer science"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T18:22:29.414401Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}