{"doi":"10.1016/j.bioactmat.2025.12.036","title":"Carrier free oral Co-delivery of atorvastatin via baicalein-copper-network for atherosclerosis therapy through senescence reversal and multi-mechanistic synergy","abstract":null,"journal":"Bioactive Materials","year":2026,"id":645734,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1221765,"name":"Gen Li","orcid":"0000-0003-3625-2210","position":1,"is_corresponding":false},{"id":206936,"name":"Xiaoyu Liang","orcid":null,"position":2,"is_corresponding":false},{"id":1681548,"name":"Changduo Wang","orcid":"0000-0002-7694-8020","position":3,"is_corresponding":false},{"id":158142,"name":"Ni Zhu","orcid":null,"position":4,"is_corresponding":false},{"id":1681549,"name":"Xue Fu","orcid":null,"position":5,"is_corresponding":false},{"id":3631,"name":"Yujie Zhang","orcid":"0000-0002-1017-0316","position":6,"is_corresponding":false},{"id":565907,"name":"Chao Liu","orcid":"0000-0003-0057-3397","position":7,"is_corresponding":false},{"id":1294847,"name":"Jing Yang","orcid":"0000-0003-3848-5958","position":8,"is_corresponding":false},{"id":1595990,"name":"Kaijing Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Carrier free oral Co-delivery of atorvastatin via baicalein-copper-network for atherosclerosis therapy through senescence reversal and multi-mechanistic synergy","abstract":"Atherosclerosis (AS) progression is driven by multiple interconnected pathological mechanisms. Among them, vascular senescence is both a key accelerator and consequence, interacting with other processes to promote AS development. Traditional monotherapies were limited to achieve synergistic therapeutic effects due to low oral bioavailability and insufficient multi-target efficacy. To overcome these limitations, we developed a baicalein-copper network (Cu-MON) for oral delivery of atorvastatin (ATV), forming a synergistic therapeutic system (CMA). Cu-MON significantly prolonged the gastrointestinal residence and increased the oral bioavailability of ATV without requiring additional excipients. Crucially, Cu-MON regulated senescence-associated genes, enhanced DNA repair pathways, and mitigated DNA damage, effectively counteracting vascular aging. The integrated CMA system combined enzymatic and non-enzymatic dual antioxidant systems to scavenge multiple ROS species. Furthermore, CMA reprogrammed macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotypes, modulated the PPAR-γ/LXR-α/ABCA-1 pathway to enhance cholesterol efflux, inhibited foam cell formation, and regulated hepatic and systemic cholesterol homeostasis. In ApoE −/− mice, CMA markedly reduced aortic plaque burden and fibrosis, while Cu-MON attenuated key features of AS, including decreased ROS, inflammation, DNA damage, and cellular senescence. The CMA demonstrates high synergistic efficacy and biosafety, offering a novel multi-target oral drug strategy for AS treatment.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41551775","pmcid":"PMC12809744","openalex_id":"https://openalex.org/W7118173661","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82072080","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82470514","title":null},{"funder_name":"Tianjin Municipal Science and Technology Committee","grant_id":"24ZXZSSS00200","title":null},{"funder_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","grant_id":"2022-I2M-3-002","title":null},{"funder_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","grant_id":"2023-I2M-2-008","title":null},{"funder_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","grant_id":"2021-12M-1-058","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"3332024083","title":null},{"funder_name":"Natural Science Foundation of Tianjin Municipality","grant_id":"24JCZDJC00420","title":null},{"funder_name":"Natural Science Foundation of Tianjin Municipality","grant_id":"2025ZD0546100","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2024M760263","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"","title":null}],"total_grants":11,"fwci":29.8807,"citation_percentile":0.99658412,"influential_citations":0,"citation_trend":[{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.bioactmat.2025.12.036","host_type":"journal"},{"url":"https://doi.org/10.1016/j.bioactmat.2025.12.036","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2452199X25006279?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2452199X25006279?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41551775","host_type":"repository"},{"url":"https://doaj.org/article/2a073fa91acd4e119ee59d82d47c6d24","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12809744/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12809744","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12809744?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Flavonoids in Medical Research","Retinal Diseases and Treatments","Advanced Glycation End Products research"],"mesh_terms":[],"keywords":["Atorvastatin","Bioavailability","Senescence","Antioxidant","Inflammation","Oral administration","DNA damage","Atherosclerosis","Anti-inflammation","Anti-aging","Ros Homeostasis","Synergistic Treatment"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T09:58:37.528433Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}