{"doi":"10.1016/j.bioactmat.2025.07.019","title":"Single-atom Pt-doped ceria nanozymes mitigate myocardial ischemia reperfusion injury via cardiomyocyte-targeted uptake and suppression of reactive oxygen species","abstract":null,"journal":"Bioactive Materials","year":2025,"id":673801,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1760471,"name":"Woo-Sup Sim","orcid":"0000-0001-7425-8192","position":1,"is_corresponding":false},{"id":1760472,"name":"Yunseong Ji","orcid":"0000-0002-2048-153X","position":2,"is_corresponding":false},{"id":1760473,"name":"Amal George Kurian","orcid":null,"position":3,"is_corresponding":false},{"id":1760474,"name":"Jung-Hwan Lee","orcid":null,"position":4,"is_corresponding":false},{"id":1760475,"name":"Thi Van Anh Bui","orcid":null,"position":5,"is_corresponding":false},{"id":1760476,"name":"Yimin Lai","orcid":null,"position":6,"is_corresponding":false},{"id":1760477,"name":"Hyesoo Hwangbo","orcid":"0009-0007-3052-5042","position":7,"is_corresponding":false},{"id":1191003,"name":"Huanhuan Sun","orcid":"0000-0001-9189-8335","position":8,"is_corresponding":false},{"id":1760478,"name":"Hae-Won Kim","orcid":null,"position":9,"is_corresponding":false},{"id":1760479,"name":"Hun-Jun Park","orcid":"0000-0001-8009-9546","position":10,"is_corresponding":false},{"id":1760480,"name":"Kiwon Ban","orcid":"0000-0003-0805-5439","position":11,"is_corresponding":false},{"id":1760470,"name":"Aoyang Pu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Single-atom Pt-doped ceria nanozymes mitigate myocardial ischemia reperfusion injury via cardiomyocyte-targeted uptake and suppression of reactive oxygen species","abstract":"The primary treatment for myocardial infarction (MI) is restoring blood flow to the obstructed coronary artery. However, this approach can paradoxically generate reactive oxygen species (ROS), leading to secondary ischemia-reperfusion (IR) injury. Multifunctional nanomaterials present a promising alternative for managing IR injury, offering benefits including cost-effectiveness, robust catalytic stability, and customizable properties that surpass traditional antioxidants. This study explores single-atom Pt-doped ceria nanozymes (Pt@CeNZ) with multi-enzyme mimetic functions facilitated by atomically dispersed Pt. The nanozymes effectively eliminate excess ROS in cardiomyocytes, thereby enhancing cell viability. Notably, Pt@CeNZ demonstrates significantly higher uptake in cardiomyocytes, underscoring its potential as a targeted nanotherapeutic for cardiac tissues. In vivo studies further confirm that Pt@CeNZ treatment substantially reduces infarct size and improves cardiac function following IR injury, without inducing long-term toxicity or inflammation. These findings position Pt@CeNZ as a highly promising heart-targeting nanotherapeutic with potential applications in the acute and long-term treatment of cardiac injuries.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40727484","pmcid":"PMC12302255","openalex_id":"https://openalex.org/W4412494240","authors":[],"funders":[{"funder_name":"City University of Hong Kong","grant_id":"9610530","title":null},{"funder_name":"City University of Hong Kong","grant_id":"9239089","title":null},{"funder_name":"City University of Hong Kong","grant_id":"9609319","title":null},{"funder_name":"City University of Hong Kong","grant_id":"9609305","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"RS-2023-00220207","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"RS-2021-NR060095","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"RS-2024-00440285","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"RS-2024-00348908","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"RS-2023-00219981","title":null},{"funder_name":"Ministry of Science and ICT, South Korea","grant_id":"","title":null}],"total_grants":10,"fwci":0.7833,"citation_percentile":0.67448631,"influential_citations":0,"citation_trend":[{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.bioactmat.2025.07.019","host_type":"journal"},{"url":"https://doi.org/10.1016/j.bioactmat.2025.07.019","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2452199X25003123?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2452199X25003123?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40727484","host_type":"repository"},{"url":"https://hdl.handle.net/2031/8a616688-9d5c-48a5-ba81-8157df19405c","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12302255","host_type":"repository"},{"url":"https://doaj.org/article/0593de98942a4f97aecaaf7b39a88eb8","host_type":"repository"},{"url":"https://scholars.cityu.edu.hk/files/301960604/298897764.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12302255","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12302255?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Advanced Nanomaterials in Catalysis","Cardiac Ischemia and Reperfusion","Fuel Cells and Related Materials"],"mesh_terms":[],"keywords":["Reactive oxygen species","Materials science","Oxygen","Doping","Chemistry","Biophysics","Optoelectronics","Biochemistry","Biology","Antioxidation","reactive oxygen species (ROS)","Ceria Nanozymes","Myocardial Ischemia-reperfusion (Ir) Injury","Cardiomyocyte-targeted"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T14:32:01.734202Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}