{"doi":"10.1016/j.bioactmat.2022.08.017","title":"Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment","abstract":null,"journal":"Bioactive Materials","year":2023,"id":660697,"datarank":0.6414999178524083,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":0.0,"self_endowment_contribution":0.6414999178524083,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1724778,"name":"Han-Jun Kim","orcid":null,"position":1,"is_corresponding":false},{"id":245312,"name":"Hossein Montazerian","orcid":"0000-0001-6972-2667","position":2,"is_corresponding":false},{"id":258846,"name":"Avijit Baidya","orcid":"0000-0001-5215-2856","position":3,"is_corresponding":false},{"id":260331,"name":"Maryam Tavafoghi","orcid":"0000-0001-5050-5822","position":4,"is_corresponding":false},{"id":258849,"name":"Yi Chen","orcid":"0000-0001-5329-4987","position":5,"is_corresponding":false},{"id":354438,"name":"Yangzhi Zhu","orcid":"0000-0003-2920-3365","position":6,"is_corresponding":false},{"id":646445,"name":"Solmaz Karamikamkar","orcid":"0000-0002-6151-1539","position":7,"is_corresponding":false},{"id":260332,"name":"Amir Sheikhi","orcid":"0000-0002-4495-6675","position":8,"is_corresponding":false},{"id":230339,"name":"Ali Khademhosseini","orcid":"0000-0002-2692-1524","position":9,"is_corresponding":false},{"id":241782,"name":"Reihaneh Haghniaz","orcid":"0000-0003-0033-891X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment","abstract":"Blood loss by hemorrhaging wounds accounts for over one-third of ∼5 million trauma fatalities worldwide every year. If not controlled in a timely manner, exsanguination can take lives within a few minutes. Developing new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical need. Here, biocompatible, and biodegradable microneedle arrays (MNAs) based on gelatin methacryloyl (GelMA) biomaterial hybridized with silicate nanoplatelets (SNs) are developed for hemorrhage control. The SNs render the MNAs hemostatic, while the needle-shaped structure increases the contact area with blood, synergistically accelerating the clotting time from 11.5 min to 1.3 min <i>in vitro</i>. The engineered MNAs reduce bleeding by ∼92% compared with the untreated injury group in a rat liver bleeding model. SN-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat <i>in vivo via</i> combining micro- and nanoengineered features. Furthermore, the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure applications. These hemostatic MNAs may enable rapid hemorrhage control, particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36439081","pmcid":"PMC9692134","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIBIB NIH HHS","grant_id":"R01 EB023052","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA257558","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK130566","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL140618","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P30 AI028697","title":null},{"funder_name":"National Institutes of Health","grant_id":"5P30AI028697-26","title":"Biostatistics Core"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK130566-04","title":"Healing enterocutaneous fistulas using bioengineered biomaterials"},{"funder_name":"National Institutes of Health","grant_id":"7R01EB023052-02","title":"Engineering a naturally derived and highly adhesive surgical sealant"},{"funder_name":"National Institutes of Health","grant_id":"5R01CA257558-04","title":"Drug eluting injectable biomaterials for next generation chemoembolization"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL140618-04","title":"Engineering highly elastic surgical sealants with hemostatic properties"},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":11,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.bioactmat.2022.08.017","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2452199X22003607?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2452199X22003607?httpAccept=text/plain","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9692134","host_type":"repository"},{"url":"https://doaj.org/article/1ee586ef8fab4316bbb15d979cc89516","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9692134","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9692134?pdf=render","host_type":"Europe_PMC"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36439081","host_type":""},{"url":"http://dx.doi.org/10.1016/j.bioactmat.2022.08.017","host_type":""}],"fields_of_study":["0301 basic medicine","02 engineering and technology","03 medical and health sciences","0210 nano-technology"],"mesh_terms":[],"keywords":["Bleeding","hemorrhage","Microneedles","Hemostat","Silicate Nanoplatelets","Gelatin Methacryloyl","QH301-705.5","Article","TA401-492","Biology (General)","Materials of engineering and construction. Mechanics of materials"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T09:44:01.463261Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}