{"doi":"10.1016/j.bioactmat.2022.03.017","title":"Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development","abstract":"MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel to treat diabetic wounds. Mice with ablation of MG53 display defective hair follicle structure, and topical application of rhMG53 can promote hair growth in the mg53−/− mice. Cell lineage tracing studies reveal a physiological function of MG53 in modulating the proliferation of hair follicle stem cells (HFSCs). We find that rhMG53 protects HFSCs from oxidative stress-induced apoptosis and stimulates differentiation of HSFCs into keratinocytes. The cytoprotective function of MG53 is mediated by STATs and MAPK signaling in HFSCs. The thermosensitive ROS-scavenging gel encapsulated with rhMG53 allows for sustained release of rhMG53 and promotes healing of chronic cutaneous wounds and hair follicle development in the db/db mice. These findings support the potential therapeutic value of using rhMG53 in combination with ROS-scavenging gel to treat diabetic wounds.","journal":"Bioactive Materials","year":2022,"id":241995,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341622,"name":"Haichang Li","orcid":"0000-0001-9784-6480","position":1,"is_corresponding":false},{"id":317180,"name":"Ya Guan","orcid":"0000-0002-6889-4966","position":2,"is_corresponding":false},{"id":872192,"name":"Xin Zhou","orcid":"0000-0002-7013-187X","position":3,"is_corresponding":false},{"id":649368,"name":"Zhong‐Guang Li","orcid":"0000-0002-6161-0377","position":4,"is_corresponding":false},{"id":649366,"name":"Li Zhao","orcid":"0000-0002-7985-1603","position":5,"is_corresponding":false},{"id":774703,"name":"Peng Chen","orcid":"0000-0001-7522-3813","position":6,"is_corresponding":false},{"id":341620,"name":"Tao Tan","orcid":"0000-0003-0231-9309","position":7,"is_corresponding":false},{"id":554568,"name":"Hua Zhu","orcid":"0000-0001-7136-7326","position":8,"is_corresponding":false},{"id":771183,"name":"Valerie Bergdall","orcid":null,"position":9,"is_corresponding":false},{"id":667390,"name":"Xuehong Xu","orcid":null,"position":10,"is_corresponding":false},{"id":341623,"name":"Jianjie Ma","orcid":"0000-0003-3865-6112","position":11,"is_corresponding":false},{"id":226025,"name":"Jianjun Guan","orcid":"0000-0002-1040-3386","position":12,"is_corresponding":false},{"id":317178,"name":"Hong Niu","orcid":"0000-0002-3249-0492","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T00:23:05.485568Z","pmid":"35387169","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}