{"doi":"10.1016/j.bioactmat.2021.12.011","title":"2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy","abstract":"An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities. We report here a dual-therapeutic prodrug, DOXjade, that allows for iron chelation chemo-photothermal cancer therapy. This prodrug takes advantage of the clinically approved iron chelator deferasirox (ExJade®) and the topoisomerase 2 inhibitor, doxorubicin (DOX). Loading DOXjade onto ultrathin 2D Ti3C2 MXene nanosheets produces a construct, Ti3C2[email protected], that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites, while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%. Antitumor mechanistic investigations reveal that upon activation, Ti3C2[email protected] serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor (TfR). A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo. The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.","journal":"Bioactive Materials","year":2021,"id":150134,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":97,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":638380,"name":"Yingwei Wang","orcid":"0000-0003-1828-8420","position":1,"is_corresponding":false},{"id":638381,"name":"Jusung An","orcid":"0000-0003-4324-2782","position":2,"is_corresponding":false},{"id":107368,"name":"Adam C. Sedgwick","orcid":"0000-0002-3132-2913","position":3,"is_corresponding":false},{"id":638382,"name":"Mingle Li","orcid":"0000-0002-0384-9128","position":4,"is_corresponding":false},{"id":639473,"name":"Jianlei Xie","orcid":null,"position":5,"is_corresponding":false},{"id":638383,"name":"Weibin Hu","orcid":"0000-0001-5944-3146","position":6,"is_corresponding":false},{"id":638384,"name":"Jianlong Kang","orcid":"0009-0003-0745-2034","position":7,"is_corresponding":false},{"id":392369,"name":"Sajal Sen","orcid":"0000-0002-1189-4156","position":8,"is_corresponding":false},{"id":572757,"name":"Axel Steinbrueck","orcid":"0000-0001-6014-3204","position":9,"is_corresponding":false},{"id":638385,"name":"Bin Zhang","orcid":"0000-0002-2112-2555","position":10,"is_corresponding":false},{"id":639474,"name":"Lijun Qiao","orcid":null,"position":11,"is_corresponding":false},{"id":638386,"name":"S. Wageh","orcid":"0000-0002-9494-4568","position":12,"is_corresponding":false},{"id":438420,"name":"Jonathan F. Arambula","orcid":"0000-0003-2342-8440","position":13,"is_corresponding":false},{"id":638387,"name":"Liping Liu","orcid":"0000-0001-7017-301X","position":14,"is_corresponding":false},{"id":543912,"name":"Han Zhang","orcid":"0000-0002-0166-1973","position":15,"is_corresponding":false},{"id":107373,"name":"Jonathan L. Sessler","orcid":"0000-0002-9576-1325","position":16,"is_corresponding":false},{"id":638388,"name":"Jong Seung Kim","orcid":"0000-0003-3477-1172","position":17,"is_corresponding":false},{"id":638379,"name":"Yunjie Xu","orcid":"0000-0003-0730-8473","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T23:43:01.325389Z","pmid":"35310350","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}