{"doi":"10.1016/j.berh.2023.101852","title":"Biomarkers for osteoarthritis: Current status and future prospects","abstract":null,"journal":"Best Practice & Research Clinical Rheumatology","year":2023,"id":628526,"datarank":0.6830815337400812,"base_score":4.553876891600541,"endowment":4.553876891600541,"self_citation_contribution":0.6830815337400812,"citation_network_contribution":0.0,"self_endowment_contribution":0.6830815337400812,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":94,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":856036,"name":"Christian S. Thudium","orcid":"0000-0002-0202-1417","position":1,"is_corresponding":false},{"id":64784,"name":"Anne‐Christine Bay‐Jensen","orcid":"0000-0001-7952-9297","position":2,"is_corresponding":false},{"id":1627349,"name":"Tazio Maleitzke","orcid":"0000-0003-2924-7384","position":3,"is_corresponding":false},{"id":1207288,"name":"Sven Geißler","orcid":"0000-0002-8750-6324","position":4,"is_corresponding":false},{"id":512283,"name":"Georg N. Duda","orcid":"0000-0001-7605-3908","position":5,"is_corresponding":false},{"id":1627350,"name":"Tobias Winkler","orcid":"0000-0003-0727-4680","position":6,"is_corresponding":false},{"id":889058,"name":"Ali Mobasheri","orcid":"0000-0001-6261-1286","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biomarkers for osteoarthritis: Current status and future prospects","abstract":"Osteoarthritis (OA) is the most common form of arthritis globally and a major cause of pain, physical disability, and loss of economic productivity, with currently no causal treatment available. This review article focuses on current research on OA biomarkers and the potential for using biomarkers in future clinical practice and clinical trials of investigational drugs. We discuss how biomarkers, specifically soluble ones, have a long path to go before reaching clinical standards of care. We also discuss how biomarkers can help in phenotyping and subtyping to achieve enhanced stratification and move toward better-designed clinical trials. We also describe how biomarkers can be used for molecular endotyping and for determining the clinical outcomes of investigational cell-based therapies. Biomarkers have the potential to be developed as surrogate end points in clinical trials and help private-public consortia and the biotechnology and pharmaceutical industries develop more effective and targeted personalized treatments and enhance clinical care for patients with OA.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37620236","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Academy of Finland","grant_id":"Profi6 336449","title":null},{"funder_name":"Innovative Medicines Initiative","grant_id":"115770","title":null},{"funder_name":"Lietuvos Mokslo Taryba","grant_id":"01.2.2-LMT-K-718-02-0022","title":null},{"funder_name":"Seventh Framework Programme","grant_id":"305815","title":"Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases"},{"funder_name":"European Social Fund Plus","grant_id":"09.3.3-LMT-K-712","title":null},{"funder_name":"European Social Fund Plus","grant_id":"09.3.3-LMT-K-712-01-0157","title":null},{"funder_name":"European Social Fund Plus","grant_id":"DOTSUT-215","title":null},{"funder_name":"HORIZON EUROPE Framework Programme","grant_id":"101095635","title":"PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES"},{"funder_name":"HORIZON EUROPE Framework Programme","grant_id":"HORIZON-HLTH-2022-STAYHLTH-02-01","title":null},{"funder_name":"European Commission","grant_id":"625746","title":null},{"funder_name":"European Commission","grant_id":"FP7-PEOPLE-2013-IEF","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Seventh Framework Programme","grant_id":"","title":null},{"funder_name":"Oulun Yliopisto","grant_id":"","title":null},{"funder_name":"European Regional Development Fund","grant_id":"","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"","title":null}],"total_grants":16,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"CC BY","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1521694223000384?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1521694223000384?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.berh.2023.101852","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/37620236","host_type":""},{"url":"http://dx.doi.org/10.1016/j.berh.2023.101852","host_type":""}],"fields_of_study":["0303 health sciences","03 medical and health sciences"],"mesh_terms":["Humans","Osteoarthritis","Biomarkers"],"keywords":["Biomarker","Clinical practice","Clinical Trials","Drug Development","Clinical Phenotype","Osteoarthritis (Oa)","Patient Stratification","Molecular Endotype","Disease-modifying Oa Drug (Dmoad)","Osteoarthritis","Humans","Biomarkers"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T13:54:41.220691Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}