{"doi":"10.1016/j.bcp.2024.116428","title":"Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation","abstract":null,"journal":"Biochemical Pharmacology","year":2024,"id":652016,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1700705,"name":"Taoli Sun","orcid":null,"position":1,"is_corresponding":false},{"id":559075,"name":"Dongmei Yang","orcid":"0000-0002-4638-3700","position":2,"is_corresponding":false},{"id":1700706,"name":"Hongqing Zhao","orcid":null,"position":3,"is_corresponding":false},{"id":1700707,"name":"Limei Lin","orcid":null,"position":4,"is_corresponding":false},{"id":1700708,"name":"Bohou Xia","orcid":null,"position":5,"is_corresponding":false},{"id":474939,"name":"Minjie Li","orcid":"0000-0002-2475-1509","position":6,"is_corresponding":false},{"id":1700709,"name":"Meihong Piao","orcid":null,"position":7,"is_corresponding":false},{"id":1365132,"name":"Zhe Shi","orcid":"0009-0008-5640-5177","position":8,"is_corresponding":false},{"id":1390627,"name":"Qinhui Tuo","orcid":"0000-0002-4157-6343","position":9,"is_corresponding":false},{"id":1700704,"name":"Sha Peng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation","abstract":"Sepsis-associated encephalopathy (SAE) is the main cause of cognitive impairment in patients with sepsis. The infiltration of inflammatory signals into the central nervous system (CNS) via the compromised blood-brain barrier (BBB) represents a crucial step in the pathological progression of SAE. In particular, T-helper 17 cell (Th17 cells) has been suggested to be highly correlated with the activation of central immune responses. Thus, preventing Th17 cell infiltration into the CNS may be a possible strategy to alleviate cognitive decline in SAE. Dipsacoside B (DB) is one of the primary active components in Chuan Xu Duan (Dipsacus asper Wall). We speculate that DB may be a potential candidate for the treatment of SAE-related cognitive deficits. In the present study, we demonstrated that DB could effectively alleviate cognitive impairment in SAE mice. DB significantly suppressed the central inflammatory response induced by repeated lipopolysaccharide (LPS) injection. The mechanism underlying its therapeutic effect should be attributed to the reduction of BBB impairment and pathogenic Th17 cell infiltration into the CNS by inhibition of vascular endothelial growth factor A (VEGFA)/ Vascular endothelial growth factor receptor 2(VEGFR2)/ Endothelial nitric oxide synthase (eNOS) signaling. Our findings suggest that DB is a potential candidate for the treatment of SAE-related cognitive dysfunction.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39009096","pmcid":null,"openalex_id":"https://openalex.org/W4400624089","authors":[],"funders":[{"funder_name":"Scientific Research Foundation of Hunan Provincial Education Department","grant_id":"","title":null}],"total_grants":1,"fwci":1.5208,"citation_percentile":0.82235301,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006295224004118?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006295224004118?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bcp.2024.116428","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39009096","host_type":"repository"}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Intensive Care Unit Cognitive Disorders","Inflammation biomarkers and pathways"],"mesh_terms":["Neuroinflammatory Diseases","Animals","Male","Mice, Inbred C57BL","Saponins","Mice","Th17 Cells","Cognitive Dysfunction","Sepsis-Associated Encephalopathy"],"keywords":["Neuroinflammation","Cognitive impairment","Sepsis","Infiltration (HVAC)","Encephalopathy","Medicine","Cognition","Inflammation","Neuroscience","Immunology","Psychology","Internal medicine","Psychiatry","Th17 Cell","Sepsis-associated Encephalopathy","Dipsacoside B"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T11:33:28.055508Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}