{"doi":"10.1016/j.bcmd.2023.102746","title":"γ′ fibrinogen levels as a biomarker of COVID-19 respiratory disease severity","abstract":"Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ′ fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO 2 ). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95 % CI 64.8–74.8) mg/dL compared with 36.9 (95 % CI 31.4–42.4) mg/dL, p < 0.0001), whereas C-reactive protein (CRP), lactate dehydrogenase (LDH), and total fibrinogen levels were not significantly different between groups. Mean GPF levels were significantly highest in patients with severe COVID-19 (SpO 2 ≤ 93 %, GPF 75.2 (95 % CI 68.7–81.8) mg/dL), compared to mild/moderate COVID-19 (SpO 2 > 93 %, GPF 62.5 (95 % CI 55.0–70.0) mg/dL, p = 0.01, AUC of 0.68, 95 % CI 0.57–0.78; Youden's index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.","journal":"Blood Cells Molecules and Diseases","year":2023,"id":360567,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1112854,"name":"Bindhya Sadhanandhan","orcid":null,"position":1,"is_corresponding":false},{"id":1112855,"name":"Sreepriya Arun","orcid":null,"position":2,"is_corresponding":false},{"id":67148,"name":"Rebecca Long","orcid":null,"position":3,"is_corresponding":false},{"id":1112856,"name":"Alicia J. Johnson","orcid":null,"position":4,"is_corresponding":false},{"id":1112857,"name":"Jamie Noll","orcid":null,"position":5,"is_corresponding":false},{"id":1112858,"name":"C. N. Ramchand","orcid":null,"position":6,"is_corresponding":false},{"id":1112368,"name":"John K. Olynyk","orcid":"0000-0003-0417-3411","position":7,"is_corresponding":false},{"id":1112369,"name":"David H. Farrell","orcid":"0000-0002-1266-0263","position":8,"is_corresponding":false},{"id":409500,"name":"Lucy Z. Kornblith","orcid":"0000-0002-1861-9691","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:14:06.433417Z","pmid":"37150704","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}