{"doi":"10.1016/j.bbrep.2024.101873","title":"StarD5 modulates B cell cholesterol synthesis and IgG1 plasma cell differentiation","abstract":"StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown. 25-HC has been recently described as an important suppressor of IgA + plasma cell differentiation in the Peyer's patches, and regulates the switch between germinal center and plasma cells. Since StarD5 regulates 25-HC, we examined the role of StarD5 in B cells using StarD5 −/− mice. We found that StarD5 −/− mice have normal B cell development and antibody production at baseline, but after T-dependent immunization a reduction in class-switched IgG1 germinal center B cells and plasma cells was observed. T-independent immune responses additionally result in a reduction in IgG1 responses and this likely B cell intrinsic. In addition, there was impairment at the T1 to T2 transitional B cell stage after T-independent immunization. In conclusion, StarD5 appears important for IgG1 responses in B cells and may regulate B cell development under stress conditions. Our findings suggest a role for StarD5 as a key regulator of B cell function and activation following immunization. • StarD5 regulates 25-HC. In mice deficient in StarD5 mice have normal B cell development and antibody production at baseline. • StarD5 deficient mice exhibit reduced IgG1 germinal center B cells and plasma cells in response to T-dependent immunization. • StarD5 deficient mice exhibit reduced IgG1 production in response to T-independent immunization.","journal":"Biochemistry and Biophysics Reports","year":2024,"id":506253,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322661,"name":"Daniel Rodrı́guez-Agudo","orcid":"0000-0002-5521-6314","position":1,"is_corresponding":false},{"id":463745,"name":"Sheela Damle","orcid":"0000-0001-6688-0950","position":2,"is_corresponding":false},{"id":322659,"name":"Genta Kakiyama","orcid":"0000-0002-0366-6903","position":3,"is_corresponding":false},{"id":324544,"name":"William M. Pandak","orcid":null,"position":4,"is_corresponding":false},{"id":139895,"name":"Gregorio Gil","orcid":null,"position":5,"is_corresponding":false},{"id":274831,"name":"Rebecca Martin","orcid":"0000-0001-9948-5463","position":6,"is_corresponding":false},{"id":276479,"name":"Anuj Tharakan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T02:10:50.984927Z","pmid":"39624792","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}