{"doi":"10.1016/j.bbrep.2022.101333","title":"Effects of zinc and carnosine on aggregation kinetics of Amyloid-β40 peptide","abstract":"The accumulation and amyloid formation of amyloid-β (Aβ) peptides is closely associated with the pathology of Alzheimer's disease. The physiological environment wherein Aβ aggregation happens is crowded with a large variety of metal ions including Zn2+. In this study, we investigated the role of Zn2+ in regulating the aggregation kinetics of Aβ40 peptide. Our results show that Zn2+ can shift a typical single sigmoidal aggregation kinetics of Aβ40 to a biphasic aggregation process. Zn2+ aids in initiating the rapid self-assembly of monomers to form oligomeric intermediates, which further grow into amyloid fibrils in the first aggregation phase. The presence of Zn2+ also retards the appearance of the second aggregation phase in a concentration dependent manner. In addition, our results show that a natural dipeptide, carnosine, can greatly alleviate the effect of Zn2+ on Aβ aggregation kinetics, most likely by coordinating with the metal ion to form chelates. These results suggest a potential in vivo protective effect of carnosine against the cytotoxicity of Aβ by suppressing Zn2+-induced rapid formation of Aβ oligomers.","journal":"Biochemistry and Biophysics Reports","year":2022,"id":267239,"datarank":0.43724560624733044,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.1076619196468975,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.1076619196468975,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":928180,"name":"Deepika Regmi","orcid":null,"position":1,"is_corresponding":false},{"id":922634,"name":"Majedul Islam","orcid":"0000-0002-7642-8105","position":2,"is_corresponding":false},{"id":927830,"name":"Dawn Raja Somu","orcid":"0000-0001-6708-6492","position":3,"is_corresponding":false},{"id":927831,"name":"Vivian Merk","orcid":"0000-0003-0685-048X","position":4,"is_corresponding":false},{"id":499643,"name":"Deguo Du","orcid":"0000-0002-8701-8208","position":5,"is_corresponding":false},{"id":928310,"name":"Fengyun Shen","orcid":null,"position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:02.050512Z","pmid":"36105613","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}