{"doi":"10.1016/j.bbrep.2022.101285","title":"Splice-site identification for exon prediction using bidirectional LSTM-RNN approach","abstract":null,"journal":"Biochemistry and Biophysics Reports","year":2022,"id":686163,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792683,"name":"Ravindra Nath","orcid":null,"position":1,"is_corresponding":false},{"id":1611101,"name":"Dev Bukhsh Singh","orcid":null,"position":2,"is_corresponding":false},{"id":400658,"name":"Noopur Singh","orcid":"0000-0002-8091-6072","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Splice-site identification for exon prediction using bidirectional LSTM-RNN approach","abstract":"Machine learning methods played a major role in improving the accuracy of predictions and classification of DNA (Deoxyribonucleic Acid) and protein sequences. In eukaryotes, Splice-site identification and prediction is though not a straightforward job because of numerous false positives. To solve this problem, here, in this paper, we represent a bidirectional Long Short Term Memory (LSTM) Recurrent Neural Network (RNN) based deep learning model that has been developed to identify and predict the splice-sites for the prediction of exons from eukaryotic DNA sequences. During the splicing mechanism of the primary mRNA transcript, the introns, the non-coding region of the gene are spliced out and the exons, the coding region of the gene are joined. This bidirectional LSTM-RNN model uses the intron features that start with splice site donor (GT) and end with splice site acceptor (AG) in order of its length constraints. The model has been improved by increasing the number of epochs while training. This designed model achieved a maximum accuracy of 95.5%. This model is compatible with huge sequential data such as the complete genome.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35663929","pmcid":"PMC9157471","openalex_id":"https://openalex.org/W4282011431","authors":[],"funders":[],"total_grants":0,"fwci":1.018,"citation_percentile":0.73722812,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S2405580822000851/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S2405580822000851/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405580822000851?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405580822000851?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrep.2022.101285","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35663929","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9157471","host_type":"repository"},{"url":"https://doaj.org/article/30bcbd1105034696b59a6968509beaf6","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9157471","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9157471?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["RNA and protein synthesis mechanisms","RNA Research and Splicing","RNA modifications and cancer"],"mesh_terms":[],"keywords":["splice","Exon","Recurrent neural network","RNA splicing","Computational biology","Intron","Computer science","Gene prediction","False positive paradox","Gene","Genome","Artificial intelligence","Coding region","Genetics","Artificial neural network","Biology","RNA","Machine Learning","Deep Learning","Splice-site","Dna, Deoxyribonucleic Acid","Rna, Ribonucleic Acid","Cds, Coding Sequence","Ann, Artificial Neural Network","Bidirectional Lstm-Rnn","Lstm-rnn, Long Short-term Memory Recurrent Neural Network"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T18:43:22.881290Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}