{"doi":"10.1016/j.bbrc.2025.151300","title":"Vitamin A deficiency and male-specific effects on heart function in mice","abstract":"Hepatic stores of Vitamin A (retinol) are mobilized and metabolized in the heart following myocardial infarction. The physiological consequences of this mobilization are poorly understood. Here we used dietary depletion in a lecithin retinol acyltransferase mutant mouse line to induce Vitamin A deficiency and investigate the effects on cardiac function and recovery from myocardial infarction. We found that uninjured Vitamin A-depleted hearts had decreased contractile function but, paradoxically, improved recovery after injury. These effects on cardiac function were specific to male mice, which experienced more rapid and severe depletion of circulating Vitamin A. Following injury, Vitamin A deficiency also caused hepatic hypolipidemia and gene expression changes in heart and liver suggesting altered metabolism contributed to cardiac phenotypes. • Vitamin A deficiency decreased cardiac contractility in uninjured male mice • Vitamin A deficiency improved recovery from myocardial function in male mice • Female mice were resistant to diet-induced Vitamin A deficiency and its effects • Changes in gene expression and lipid metabolism accompanied altered heart function","journal":"Biochemical and Biophysical Research Communications","year":2025,"id":549939,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":343768,"name":"Elena Chepurko","orcid":"0000-0001-8335-5525","position":1,"is_corresponding":false},{"id":684044,"name":"Vadim Chepurko","orcid":null,"position":2,"is_corresponding":false},{"id":1445333,"name":"Grazina A Mangoba","orcid":null,"position":3,"is_corresponding":false},{"id":1444598,"name":"Mary Ann Asson–Batres","orcid":"0000-0002-4175-7128","position":4,"is_corresponding":false},{"id":323271,"name":"Calvin Vary","orcid":"0000-0001-8793-0128","position":5,"is_corresponding":false},{"id":1133557,"name":"Douglas Sawyer","orcid":"0009-0006-7584-0700","position":6,"is_corresponding":false},{"id":312498,"name":"Ian M. Gans","orcid":"0000-0003-3827-6494","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:54:12.321988Z","pmid":"39818189","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}