{"doi":"10.1016/j.bbrc.2024.149659","title":"Identification of an alternative short ARID5B isoform associated with B-ALL survival","abstract":"Utilizing RNA sequence (RNA-Seq) splice junction data from a cohort of 1841 B-cell acute lymphoblastic leukemia (B-ALL) patients we define transcriptionally distinct isoforms of ARID5B, a risk-associated gene identified in genome wide association studies (GWAS), which associate with disease survival. Short (S) and long (L) ARID5B transcripts, which differ in an encoded BAH-like chromatin interaction domain, show remarkable correlation to the isoform splicing pattern. Testing of the ARID5B proximal promoter of the S & L isoforms indicated that both are functionally independent in luciferase reporter assays. Increased short isoform expression is associated with decreased event-free and overall survival. The abundance of short and long transcripts strongly correlates to B-ALL prognostic stratification, where B-ALL subtypes with poor outcomes express a higher proportion of the S-isoform. These data demonstrate that the analysis of independent promoters and alternative splicing events are essential for improved risk stratification and a more complete understanding of disease pathology.","journal":"Biochemical and Biophysical Research Communications","year":2024,"id":494377,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":352871,"name":"Zunsong Hu","orcid":"0000-0003-3167-7148","position":1,"is_corresponding":false},{"id":322910,"name":"Min Li","orcid":"0000-0003-2796-294X","position":2,"is_corresponding":false},{"id":892910,"name":"Jennifer Kelly Shepphird","orcid":"0000-0001-6963-0228","position":3,"is_corresponding":false},{"id":253485,"name":"Zhaohui Gu","orcid":"0000-0003-1581-1327","position":4,"is_corresponding":false},{"id":1263118,"name":"Purnima Gyawali","orcid":"0000-0003-3738-2260","position":5,"is_corresponding":false},{"id":414993,"name":"Keiichi Itakura","orcid":null,"position":6,"is_corresponding":false},{"id":1140626,"name":"Garrett P. Larson","orcid":"0000-0001-8146-6010","position":7,"is_corresponding":false},{"id":1140624,"name":"Jaya Prakash Chalise","orcid":"0000-0001-6462-2819","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:09:11.736910Z","pmid":"38382358","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}