{"doi":"10.1016/j.bbrc.2020.08.117","title":"A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2020,"id":623201,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":663039,"name":"Yanting Huang","orcid":"0000-0002-3024-8942","position":1,"is_corresponding":false},{"id":1610552,"name":"Ahmidin Wali","orcid":null,"position":2,"is_corresponding":false},{"id":284719,"name":"Abulimiti Yili","orcid":"0000-0002-3435-8372","position":3,"is_corresponding":false},{"id":471320,"name":"Mingqiang Rong","orcid":"0000-0002-4865-1035","position":4,"is_corresponding":false},{"id":1610551,"name":"Atikan Wubulikasimu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans","abstract":"Due to the increasing drug-resistant of Candida albicans (C. albicans), there is an urgent need to develop a novel therapeutic agent for C. albicans induced inflammatory disease treatment. Antimicrobial peptides (AMPs) are regarded as one of the most promising antifungal drugs. However, most of the designed AMPs showed side-effects. In the present study, 10 novel peptides were designed based on the sequence of frog skin secretions peptide (Ranacyclin AJ). Among them, AKK8 (RWRFKWWKK) exhibited the strongest antifungal effect against both standard and clinically isolated drug-resistant C. albicans. AKK8 killed C. albicans (within 30 min), and the antifungal effect lasted for 24 h, showed an efficient and long lasted antifungal effect against C. albicans. Notably, AKK8 showed low toxicity to human red blood cells and high stability in human serum. Moreover, AKK8 administration showed therapeutic effects on systemic infections mice induced by the clinical drug-resistant C. albicans, in a dose-depended manner. These findings suggested that AKK8 may be a potential candidate for the anti-inflammation treatments for diseases caused by clinical drug-resistant C. albicans.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32972753","pmcid":null,"openalex_id":"https://openalex.org/W3088952809","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81573320","title":null},{"funder_name":"National Major Science and Technology Project of China","grant_id":"2017ZX09301045","title":null},{"funder_name":"CAS\"Light of West China\" Program","grant_id":"Y92S201401","title":null},{"funder_name":"CAS\"Light of West China\" Program","grant_id":"Y92S211401","title":null},{"funder_name":"CAS","grant_id":"CAS-LWC-2017-1","title":null}],"total_grants":5,"fwci":1.0439,"citation_percentile":0.74172333,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X20317241?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X20317241?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2020.08.117","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32972753","host_type":"repository"}],"fields_of_study":["Antimicrobial Peptides and Activities","Biochemical and Structural Characterization","Protein Hydrolysis and Bioactive Peptides","Medicine","Animals","Antifungal Agents","Candida albicans","Candidiasis","Cell Membrane","Cytokines","Drug Design","Drug Resistance, Fungal","Hemolysis","Humans","Mice","Peptides"],"mesh_terms":["Animals","Antifungal Agents","Candida albicans","Candidiasis","Cell Membrane","Hemolysis","Humans","Peptides","Drug Design","Cytokines","Drug Resistance, Fungal","Mice"],"keywords":["Candida albicans","Corpus albicans","Drug","Antifungal drug","Microbiology","Antifungal","Pharmacology","Antimicrobial","Peptide","Biology","Medicine","Biochemistry","antifungal peptide","Systemic Infection"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T22:47:32.688761Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}