{"doi":"10.1016/j.bbrc.2019.08.149","title":"Cdc42-mediated supracellular cytoskeleton induced cancer cell migration under low shear stress","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2019,"id":668581,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463093,"name":"Hua Jiang","orcid":"0000-0002-7561-3085","position":1,"is_corresponding":false},{"id":525139,"name":"Wei Zhao","orcid":"0000-0001-9437-3198","position":2,"is_corresponding":false},{"id":619031,"name":"Yao Meng","orcid":"0000-0003-2013-5183","position":3,"is_corresponding":false},{"id":852632,"name":"Ji Li","orcid":"0000-0003-0931-5562","position":4,"is_corresponding":false},{"id":1745912,"name":"Tongwei Huang","orcid":null,"position":5,"is_corresponding":false},{"id":1323937,"name":"Jinghui Sun","orcid":"0000-0001-5651-9862","position":6,"is_corresponding":false},{"id":292715,"name":"Lingling Liu","orcid":"0000-0003-0039-7098","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cdc42-mediated supracellular cytoskeleton induced cancer cell migration under low shear stress","abstract":"Tumor microenvironment is composed of biological, chemical and physical factors. Mechanical factors are more and more focused these years. Therefore, mimicking mechanical factors' contribution to cancer cell malignancy will greatly improve the advance in this field. Although the induced malignant behaviors are present under many stimuli such as growth or inflammatory factors, the cell key physical migration mechanisms are still missing. In this study, we identify that low shear stress significantly promotes the formation of needle-shaped membrane protrusions, which is called filopodia and important for the sense and interact of a cell with extracellular matrix in the tumor microenvironment. Under low shear stress, the migration is promoted while it is inhibited in the presence of ROCK inhibitor Y27632, which could abolish the F-actin network. Using cell imaging, we further unravel that key to these protrusions is Cell division cycle 42 (Cdc42) dependent. After Cdc42 activation, the filopodia is more and longer, acting as massagers to pass the information from a cell to the microenvironment for its malignant phenotype. In the Cdc42 inhibition, the filopodia is greatly reduced. Moreover, small GTPases Cdc42 rather than Rac1 and Rho directly controls the filopodia formation. Our work highlights that low shear stress and Cdc42 activation are sufficient to promote filopodia formation, it not only points out the novel structure for cancer progression but also provides the experimental physical basis for the efficient drug anti-cancer strategies.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31477271","pmcid":null,"openalex_id":"https://openalex.org/W2970208461","authors":[],"funders":[{"funder_name":"Technology Innovation R&D Project of Chengdu Science and Technology Bureau","grant_id":"2018-YFYF-00158-SN","title":null},{"funder_name":"The Research Fund of Development and Regeneration Key Laboratory of Sichuan Province","grant_id":"SYS18-08","title":null},{"funder_name":"Chengdu Medical College","grant_id":"CYZ16-13","title":null},{"funder_name":"Chengdu Medical College","grant_id":"CYZ17-20","title":null},{"funder_name":"General Program of School of Laboratory Medicine","grant_id":"JYZK201601","title":null},{"funder_name":"Health Department of Sichuan Province","grant_id":"18PJ002","title":null},{"funder_name":"Key Project of Sichuan Education Department","grant_id":"18ZA0141","title":null},{"funder_name":"General Program of School of Laboratory Medicine","grant_id":"JYZK201702","title":null},{"funder_name":"The Research Fund of Development and Regeneration Key Laboratory of Sichuan Province","grant_id":"SYS16-009","title":null},{"funder_name":"Collaborative Innovation Center of Sichuan for Elderly Care and Health","grant_id":"YLZBZ1802","title":null}],"total_grants":10,"fwci":1.3206,"citation_percentile":0.77435537,"influential_citations":0,"citation_trend":[{"year":2020,"count":5},{"year":2021,"count":1},{"year":2022,"count":7},{"year":2023,"count":4},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X1931678X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X1931678X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2019.08.149","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31477271","host_type":"repository"},{"url":"https://hdl.handle.net/1805/23604","host_type":"repository"},{"url":"http://hdl.handle.net/1805/23604","host_type":"repository"}],"fields_of_study":["Cellular Mechanics and Interactions","Microtubule and mitosis dynamics","Erythrocyte Function and Pathophysiology","Amides","Breast Neoplasms","Cell Movement","Cytoskeleton","Female","Humans","Pyridines","Stress, Mechanical","Tumor Cells, Cultured","cdc42 GTP-Binding Protein"],"mesh_terms":["Amides","Breast Neoplasms","Cell Movement","Cytoskeleton","Female","Humans","Pyridines","Stress, Mechanical","Tumor Cells, Cultured","cdc42 GTP-Binding Protein"],"keywords":["Filopodia","CDC42","Cell migration","Lamellipodium","Cell biology","RAC1","Stress fiber","Chemistry","Cancer cell","Extracellular matrix","Focal adhesion","Actin cytoskeleton","Actin","Cell","Cytoskeleton","Cancer","Biology","Signal transduction","Biochemistry","Migration","Low shear stress","Mechanotransduction"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T12:01:16.460462Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}