{"doi":"10.1016/j.bbrc.2017.11.080","title":"Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2018,"id":592964,"datarank":1.2875573907778122,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.7988429100745897,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.7988429100745897,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":22,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1517480,"name":"Mario Thiego F. Pacheco","orcid":null,"position":1,"is_corresponding":false},{"id":1283273,"name":"Ping Chen","orcid":"0000-0001-5437-6538","position":2,"is_corresponding":false},{"id":339646,"name":"Dan Liang","orcid":"0000-0003-2404-3075","position":3,"is_corresponding":false},{"id":767905,"name":"Wei Li","orcid":"0000-0001-9566-8764","position":4,"is_corresponding":false},{"id":1517479,"name":"Fen Tang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway","abstract":"Secretogranin III (Scg3) was recently discovered as the first highly diabetic retinopathy-associated angiogenic factor, and its neutralizing antibody alleviated the disease with high efficacy in diabetic mice. Investigation of its molecular mechanisms will facilitate the translation of this novel therapy. Scg3 was reported to induce the phosphorylation of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK). Here we characterized the importance of MEK/ERK activation to Scg3 angiogenic activity. Our results showed that MEK inhibitor PD98059 blocked Scg3-induced proliferation of human umbilical vein endothelial cells (HUVECs). This finding was corroborated by PD98059 inhibition of HUVEC migration and tube formation. Furthermore, ERK inhibitor SCH772984 also suppressed Scg3-induced proliferation and migration of HUVECs. Taken together, these findings suggest that MEK-ERK pathway plays an important role in Scg3-induced angiogenesis.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29154827","pmcid":"PMC5736013","openalex_id":"https://openalex.org/W2770034320","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"P30-EY014801","title":null},{"funder_name":"National Institutes of Health","grant_id":"R21EY027065","title":null},{"funder_name":"Research to Prevent Blindness","grant_id":"[2016] 3100","title":null},{"funder_name":"NEI NIH HHS","grant_id":"P30 EY014801","title":null}],"total_grants":4,"fwci":1.5477,"citation_percentile":0.8321857,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"green","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5736013","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5736013","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X17322581?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X17322581?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2017.11.080","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29154827","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC5736013","host_type":"repository"}],"fields_of_study":["Retinal Diseases and Treatments","Retinal Development and Disorders","Glaucoma and retinal disorders"],"mesh_terms":["Cells, Cultured","Chromogranins","Humans","Neovascularization, Pathologic","MAP Kinase Signaling System","Angiogenic Proteins","Endothelial Cells","Cell Proliferation"],"keywords":["MAPK/ERK pathway","Angiogenesis","MEK inhibitor","Umbilical vein","Kinase","Protein kinase A","Cell biology","Human umbilical vein endothelial cell","Cancer research","Signal transduction","Mitogen-activated protein kinase kinase","Mitogen-activated protein kinase","Phosphorylation","Chemistry","Biology","Biochemistry","MEK","ERK","Angiogenic Factor","Scg3","Secretogranin Iii"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T16:26:24.751185Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}