{"doi":"10.1016/j.bbrc.2015.10.039","title":"Shikonin inhibits adipogenic differentiation via regulation of mir-34a-FKBP1B","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2015,"id":597822,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1493605,"name":"Chang Hwa Jung","orcid":null,"position":1,"is_corresponding":false},{"id":1435452,"name":"Jiyun Ahn","orcid":"0000-0001-8197-893X","position":2,"is_corresponding":false},{"id":1531620,"name":"So Young Gwon","orcid":null,"position":3,"is_corresponding":false},{"id":1531621,"name":"Tae Youl Ha","orcid":null,"position":4,"is_corresponding":false},{"id":1531619,"name":"Young Jin Jang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Shikonin inhibits adipogenic differentiation via regulation of mir-34a-FKBP1B","abstract":"Shikonin is a naturally occurring naphthoquinone pigment and a major constituent present in Lithospermum erythrorhizon. Since microRNAs (miRNAs) are one of the key post-transcriptional regulators of adipogenesis, their manipulation represents a potential new strategy to inhibit adipogenesis. Our aim was to investigate shikonin-dependent inhibition of adipogenesis with an emphasis on miRNA-related processes. Mir-34a increased during induced adipogenesis, and this was suppressed in the presence of shikonin. mRNA expression of FKBP1B, a suggested target of mir-34a according to bioinformatics studies, decreased during adipogenesis, but was recovered by shikonin treatment, which reversely correlated with mir-34a expression. A mir-34a inhibitor suppressed MDI-induced adipogenesis by blocking PPARγ and C/EBPα expression, while suppression of mir-34a recovered MDI-induced down-regulation of FKBP1B expression. A mir-34a mimic decreased FKBP1B mRNA expression in 3T3-L1 preadipocytes. We also observed that mir-34a bound directly to the 3'-untranslated region of FKBP1B. Finally, FKBP1B overexpression attenuated MDI-induced adipogenesis, PPARγ, and C/EBPα expression. These results suggest that mir-34a regulates adipogenesis by targeting FKBP1B expression. Our findings reveal that shikonin prevents adipogenesis by blocking the mir-34a-FKBP1B pathway which represents a promising potential target for preventing obesity.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26471303","pmcid":null,"openalex_id":"https://openalex.org/W1889378448","authors":[],"funders":[{"funder_name":"Korea Food Research Institute","grant_id":"E0080201-08","title":null}],"total_grants":1,"fwci":1.3777,"citation_percentile":0.76718529,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":5},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X15307397?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X15307397?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2015.10.039","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26471303","host_type":"repository"}],"fields_of_study":["Bioactive Compounds and Antitumor Agents","MicroRNA in disease regulation","Plant Molecular Biology Research","3T3-L1 Cells","Adipocytes","Adipogenesis","Animals","Cell Differentiation","Mice","MicroRNAs","Naphthoquinones","Tacrolimus Binding Proteins"],"mesh_terms":["Animals","Cell Differentiation","Naphthoquinones","Adipocytes","Tacrolimus Binding Proteins","MicroRNAs","3T3-L1 Cells","Adipogenesis","Mice"],"keywords":["Adipogenesis","microRNA","Chemistry","Cell biology","Messenger RNA","Biology","Biochemistry","Adipose tissue","Gene","FKBP1B","Mir-34a","Shikonin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T14:21:06.070869Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}