{"doi":"10.1016/j.bbrc.2014.11.076","title":"A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2015,"id":633759,"datarank":0.6038027536102726,"base_score":4.02535169073515,"endowment":4.02535169073515,"self_citation_contribution":0.6038027536102726,"citation_network_contribution":0.0,"self_endowment_contribution":0.6038027536102726,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1643318,"name":"Izabela Koryga","orcid":null,"position":1,"is_corresponding":false},{"id":689799,"name":"Sharon A. Glynn","orcid":"0000-0003-1459-2580","position":2,"is_corresponding":false},{"id":514709,"name":"Sanjeev Gupta","orcid":"0000-0002-5818-7280","position":3,"is_corresponding":false},{"id":1643320,"name":"Adrienne M. Gorman","orcid":null,"position":4,"is_corresponding":false},{"id":634984,"name":"Afshin Samali","orcid":"0000-0002-8610-8375","position":5,"is_corresponding":false},{"id":1643316,"name":"Shane Deegan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy","abstract":"Endoplasmic reticulum (ER) stress is known to lead to activation of both the unfolded protein response (UPR) and autophagy. Although regulatory connections have been identified between the UPR and autophagy, it is still unclear to what extent the UPR regulates the genes involved at the different stages of the autophagy pathway. Here, we carried out a microarray analysis of HCT116 cells subjected to ER stress and observed the transcriptional upregulation of a large cohort of autophagy-related genes. Of particular interest, we identified the transcriptional upregulation of the autophagy receptor genes SQSTM1/p62, NBR1 and BNIP3L/NIX in response to ER stress and show that the inhibition of the UPR transmembrane receptors, PERK and IRE1, abrogates this upregulation.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25475719","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Health Research Board","grant_id":"HRA_HSR/2010/24","title":null},{"funder_name":"Science Foundation Ireland","grant_id":"05/IN3/B851","title":"Mediators and regulators of ER stress induced apoptosis"},{"funder_name":"Science Foundation Ireland","grant_id":"06/RFP/BIC002","title":"Regulation of endoplasmic reticulum (ER) stress-induced apoptosis and unfolded protein response (UPR) by Bcl-2 family members"},{"funder_name":"Health Research Board","grant_id":"unidentified","title":"unidentified"}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X1402107X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X1402107X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2014.11.076","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/25475719","host_type":""},{"url":"https://dx.doi.org/10.1016/j.bbrc.2014.11.076","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["DNA, Complementary","Gene Expression Profiling","Tumor Suppressor Proteins","Intracellular Signaling Peptides and Proteins","Membrane Proteins","Proteins","Protein Serine-Threonine Kinases","Endoplasmic Reticulum Stress","HCT116 Cells","eIF-2 Kinase","Gene Expression Regulation","Proto-Oncogene Proteins","Endoribonucleases","Sequestosome-1 Protein","Autophagy","Unfolded Protein Response","Humans","Adaptor Proteins, Signal Transducing","Oligonucleotide Array Sequence Analysis"],"sdg_mappings":[{"sdg_number":4,"sdg_label":"4. 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