{"doi":"10.1016/j.bbrc.2014.04.165","title":"Expression of filaggrin-2 protein in the epidermis of human skin diseases: A comparative analysis with filaggrin","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2014,"id":599031,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1535303,"name":"Megumi Mizawa","orcid":null,"position":1,"is_corresponding":false},{"id":1535304,"name":"Takako Yamakoshi","orcid":null,"position":2,"is_corresponding":false},{"id":1535305,"name":"Mikiro Takaishi","orcid":null,"position":3,"is_corresponding":false},{"id":1535306,"name":"Tadamichi Shimizu","orcid":null,"position":4,"is_corresponding":false},{"id":1535302,"name":"Teruhiko Makino","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression of filaggrin-2 protein in the epidermis of human skin diseases: A comparative analysis with filaggrin","abstract":"Filaggrin-2 is a member of the S100 fused-type protein family, and the structural features and expression of filaggrin-2 are similar to those of profilaggrin, a protein essential for keratinization. In the present study, we investigated the expression profile of filaggrin-2 in patients with skin diseases using antibodies against the repetitive region of filaggrin-2. In tissue samples from patients with skin diseases which are associated with a decrease in filaggrin, including ichthyosis vulgaris, atopic dermatitis and psoriasis vulgaris, the expression level of filaggrin-2 was markedly decreased compared to that in normal skin samples. In contrast, the expression of filaggrin-2 increased in parallel with that of filaggrin in samples of tissue from patients with skin diseases associated with hyperkeratosis, such as lichen planus and epidermolytic ichthyosis. Interestingly, filaggrin-2 signals were observed in slightly higher layers of the epidermis in comparison to those of filaggrin. Similarly, the expression of filaggrin-2 proteins was induced slightly later than filaggrin in the cultured keratinocytes. These findings suggest that filaggrin-2 may play an overlapping role with filaggrin in epithelial cornification; however, it may also have a partially distinct role in the molecular processes of cornification.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24813994","pmcid":null,"openalex_id":"https://openalex.org/W2013921608","authors":[],"funders":[{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"","title":null}],"total_grants":1,"fwci":4.1311,"citation_percentile":0.93779762,"influential_citations":0,"citation_trend":[{"year":2015,"count":6},{"year":2016,"count":3},{"year":2017,"count":5},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X14008444?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X14008444?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2014.04.165","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24813994","host_type":"repository"}],"fields_of_study":["Dermatology and Skin Diseases","Nail Diseases and Treatments","Allergic Rhinitis and Sensitization","Cells, Cultured","Epidermis","Filaggrin Proteins","Humans","Intermediate Filament Proteins","S100 Proteins","Skin Diseases","Tissue Distribution"],"mesh_terms":["Filaggrin Proteins","Cells, Cultured","Epidermis","Humans","Intermediate Filament Proteins","S100 Proteins","Skin Diseases","Tissue Distribution"],"keywords":["Filaggrin","Ichthyosis vulgaris","Epidermis (zoology)","Atopic dermatitis","Dermatology","Keratin","Biology","Medicine","Immunology","Pathology","Anatomy","Psoriasis vulgaris","Filaggrin-2","S100 Fused-protein Family"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:51:01.235677Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}