{"doi":"10.1016/j.bbrc.2012.12.148","title":"Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2013,"id":670469,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259553,"name":"Qi Long","orcid":"0000-0003-0660-5230","position":1,"is_corresponding":false},{"id":1751345,"name":"Keshi Chen","orcid":null,"position":2,"is_corresponding":false},{"id":1751346,"name":"Shengbiao Li","orcid":null,"position":3,"is_corresponding":false},{"id":1751347,"name":"Ge Xiang","orcid":null,"position":4,"is_corresponding":false},{"id":1196491,"name":"Shen Chen","orcid":null,"position":5,"is_corresponding":false},{"id":1751349,"name":"Xiyin Liu","orcid":null,"position":6,"is_corresponding":false},{"id":449696,"name":"Yuxing Li","orcid":"0000-0001-9785-2960","position":7,"is_corresponding":false},{"id":552217,"name":"Liang Yang","orcid":"0009-0007-2903-641X","position":8,"is_corresponding":false},{"id":1751350,"name":"Delu Dong","orcid":null,"position":9,"is_corresponding":false},{"id":1326784,"name":"Cheng Jiang","orcid":"0009-0001-5782-4209","position":10,"is_corresponding":false},{"id":1751351,"name":"Zhenhua Feng","orcid":null,"position":11,"is_corresponding":false},{"id":1042737,"name":"Dajiang Qin","orcid":"0009-0008-2792-3514","position":12,"is_corresponding":false},{"id":675592,"name":"Xingguo Liu","orcid":"0000-0001-7060-8204","position":13,"is_corresponding":false},{"id":1688580,"name":"Wenbo Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation","abstract":"Induced pluripotent stem cells (iPSCs) hold great clinical potential for regenerative medicine. Much work has been done to investigate the mechanisms of their generation, focusing on the cell nucleus. However, the roles of specific organelles and in particular mitochondria in the potential mechanisms of nuclear reprogramming remain unclear. In this study, we sought to determine the role of mitochondrial metabolism transition in nuclear reprogramming. We found that the mitochondrial cristae had remodeled in iPSCs. The efficiency of iPSC generation was significantly reduced by down-regulation of mitochondrial inner membrane protein (IMMT), which regulates the morphology of mitochondrial cristae. Moreover, cells with the oxidative phosphorylation (OXPHOS) advantage had higher reprogramming efficiency than normal cells and the glycolysis intermediate lactic acid enhanced the efficiency of iPSCs generation. Our results show that the remodeling of mitochondrial cristae couples with the generation of iPSCs, suggesting mitochondrial metabolism transition plays an important role in nuclear reprogramming.","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23333381","pmcid":null,"openalex_id":"https://openalex.org/W2058458809","authors":[],"funders":[{"funder_name":"Chinese Academy of Sciences","grant_id":"XDA01020108","title":null},{"funder_name":"National Science Fund for Distinguished Young Scholars","grant_id":"S20120011368","title":null}],"total_grants":2,"fwci":1.9239,"citation_percentile":0.85767566,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":4},{"year":2016,"count":6},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X13000934?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X13000934?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2012.12.148","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23333381","host_type":"repository"}],"fields_of_study":["Pluripotent Stem Cells Research","Mitochondrial Function and Pathology","CRISPR and Genetic Engineering","Animals","Cell Differentiation","Cellular Reprogramming","Glycolysis","Induced Pluripotent Stem Cells","Mice","Mitochondria","Mitochondrial Proteins","Muscle Proteins","Oxidative Phosphorylation"],"mesh_terms":["Animals","Cell Differentiation","Glycolysis","Mitochondria","Muscle Proteins","Oxidative Phosphorylation","Mitochondrial Proteins","Mice","Induced Pluripotent Stem Cells","Cellular Reprogramming"],"keywords":["Reprogramming","Induced pluripotent stem cell","Cell biology","Mitochondrion","Biology","Oxidative phosphorylation","Mitochondrial DNA","mitochondrial fusion","Cell","Organelle","Stem cell","Biochemistry","Embryonic stem cell","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T22:13:20.284147Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}