{"doi":"10.1016/j.bbrc.2012.12.138","title":"Osterix is required for cranial neural crest-derived craniofacial bone formation","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2013,"id":662938,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1730728,"name":"Young-Ji Kim","orcid":null,"position":1,"is_corresponding":false},{"id":89942,"name":"Benoit de Crombrugghe","orcid":null,"position":2,"is_corresponding":false},{"id":1730729,"name":"Jung-Eun Kim","orcid":null,"position":3,"is_corresponding":false},{"id":1730727,"name":"Wook-Young Baek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Osterix is required for cranial neural crest-derived craniofacial bone formation","abstract":"Osx plays essential roles in regulating osteoblast and chondrocyte differentiation, and bone formation during mouse skeletal development. However, many questions remain regarding the requirement for Osx in different cell lineages. In this study, we asked whether Osx is required for craniofacial bone formation derived from cranial neural crest (CNC) cells. The Osx gene was conditionally inactivated in CNC-derived cells using a Wnt1-Cre recombination system. Neural crest-specific inactivation of Osx resulted in the complete absence of intramembranous skeletal elements derived from the CNC, and CNC-derived endochondral skeletal elements were also affected by Osx inactivation. Interestingly, Osx inactivated CNC-derived cells, which were recapitulated by lacZ expression, occupied the same regions of craniofacial skeletal elements as observed for controls. However, cells lost their osteogenic ability to differentiate into functional osteoblasts by Osx inactivation. These results suggest that Osx is important for craniofacial bone formation by CNC-derived cells. This finding provides novel insights of the regulation of craniofacial development by the gene network and transcription factors, and the understanding of human diseases caused by neural crest developmental abnormalities.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23313488","pmcid":"PMC4012829","openalex_id":"https://openalex.org/W1968353452","authors":[],"funders":[{"funder_name":"Ministry of Education, Science and Technology","grant_id":"2012R1A1A2007161","title":null},{"funder_name":"Ministry of Education, Science and Technology","grant_id":"2012R1A6A3A01017109","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR049072","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"","title":null}],"total_grants":4,"fwci":0.5503,"citation_percentile":0.64952793,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X13000326?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X13000326?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2012.12.138","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23313488","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4012829","host_type":"repository"}],"fields_of_study":["Bone Metabolism and Diseases","Craniofacial Disorders and Treatments","dental development and anomalies","Animals","Craniofacial Abnormalities","Facial Bones","Gene Silencing","Integrases","Mice","Mice, Transgenic","Neural Crest","Osteogenesis","Sp7 Transcription Factor","Transcription Factors","Wnt1 Protein"],"mesh_terms":["Sp7 Transcription Factor","Animals","Facial Bones","Mice, Transgenic","Neural Crest","Osteogenesis","Transcription Factors","Integrases","Craniofacial Abnormalities","Gene Silencing","Wnt1 Protein","Mice"],"keywords":["Neural crest","Craniofacial","Intramembranous ossification","Cranial neural crest","Cell biology","Osteoblast","Biology","Endochondral ossification","Transcription factor","Anatomy","Gene","Genetics","Embryo","Cartilage"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T18:29:23.256728Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}