{"doi":"10.1016/j.bbrc.2011.06.184","title":"DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2011,"id":654989,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":234869,"name":"Vilhelm A. Bohr","orcid":"0000-0003-4823-6429","position":1,"is_corresponding":false},{"id":1709562,"name":"Byungchan Ahn","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease","abstract":"Werner syndrome (WS) is an autosomal recessive premature aging disorder characterized by aging-related phenotypes and genomic instability. WS is caused by mutations in a gene encoding a nuclear protein, Werner syndrome protein (WRN), a member of the RecQ helicase family, that interestingly possesses both helicase and exonuclease activities. Previous studies have shown that the two activities act in concert on a single substrate. We investigated the effect of a DNA secondary structure on the two WRN activities and found that a DNA secondary structure of the displaced strand during unwinding stimulates WRN helicase without coordinate action of WRN exonuclease. These results imply that WRN helicase and exonuclease activities can act independently, and we propose that the uncoordinated action may be relevant to the in vivo activity of WRN.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21763283","pmcid":"PMC4586246","openalex_id":"https://openalex.org/W1994868835","authors":[],"funders":[{"funder_name":"Ministry of Education, Science and Technology","grant_id":"2009-0094050","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"ZIA AG000721","title":null},{"funder_name":"University of Ulsan","grant_id":"","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"","title":null}],"total_grants":4,"fwci":0.2433,"citation_percentile":0.54168352,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2019,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4586246","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4586246","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X11011971?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X11011971?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2011.06.184","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21763283","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","Carcinogens and Genotoxicity Assessment","DNA and Nucleic Acid Chemistry","DNA","Exodeoxyribonucleases","Humans","Nucleic Acid Conformation","Oligonucleotides","RecQ Helicases","Substrate Specificity","Werner Syndrome","Werner Syndrome Helicase"],"mesh_terms":["Werner Syndrome Helicase","DNA","Exodeoxyribonucleases","Humans","Nucleic Acid Conformation","Oligonucleotides","Substrate Specificity","Werner Syndrome","RecQ Helicases"],"keywords":["Helicase","Exonuclease","Werner syndrome","Genome instability","DNA","Biology","Premature aging","Genetics","Molecular biology","Gene","DNA damage","DNA polymerase"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T09:12:59.412271Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}