{"doi":"10.1016/j.bbrc.2009.11.115","title":"Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2010,"id":600988,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1540862,"name":"Qing Ge","orcid":null,"position":1,"is_corresponding":false},{"id":1540863,"name":"R. Max Wynn","orcid":null,"position":2,"is_corresponding":false},{"id":418869,"name":"Seiji Ishii","orcid":null,"position":3,"is_corresponding":false},{"id":1540864,"name":"Kosaku Uyeda","orcid":null,"position":4,"is_corresponding":false},{"id":116218,"name":"Masashi Fukasawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site","abstract":"Carbohydrate response element binding protein (ChREBP) is responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression of the enzymes that channel glycolytic pyruvate into lipogenesis. The activation of ChREBP in response to high glucose is nuclear localization and transcription, and the inactivation of ChREBP under low glucose involves export from the nucleus to the cytosol. Here we report a new nuclear export signal site (\"NES1\") of ChREBP. Together these signals provide ChREBP with two NES sequences, both the previously reported NES2 and now the new NES1 coordinate to interact together with CRM1 (exportin) for nuclear export of the carbohydrate response element binding protein.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20025850","pmcid":null,"openalex_id":"https://openalex.org/W2063595078","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK063948","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK063948","title":null}],"total_grants":2,"fwci":1.259,"citation_percentile":0.78317382,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":4},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X09023110?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X09023110?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2009.11.115","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20025850","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","Nuclear Structure and Function","Cholesterol and Lipid Metabolism"],"mesh_terms":["Exportin 1 Protein","Amino Acid Sequence","Animals","Cells, Cultured","Glucose","Humans","Molecular Sequence Data","Mutation","Receptors, Cytoplasmic and Nuclear","Karyopherins","Nuclear Export Signals","Mice","Rats","Basic Helix-Loop-Helix Leucine Zipper Transcription Factors"],"keywords":["Carbohydrate-responsive element-binding protein","Nuclear export signal","Nuclear localization sequence","Biochemistry","Nuclear transport","Lipogenesis","Transcription factor","Chemistry","Cell biology","Cytosol","Cell nucleus","Biology","Enzyme","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T14:46:28.728861Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}