{"doi":"10.1016/j.bbrc.2007.11.081","title":"Concurrent expression of heme oxygenase-1 and p53 in human retinal pigment epithelial cell line","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2008,"id":671968,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1755565,"name":"Hong Jae Jo","orcid":null,"position":1,"is_corresponding":false},{"id":1755566,"name":"Kang Mi Kim","orcid":null,"position":2,"is_corresponding":false},{"id":1755567,"name":"Ju Dong Song","orcid":null,"position":3,"is_corresponding":false},{"id":1755568,"name":"Hun Taeg Chung","orcid":null,"position":4,"is_corresponding":false},{"id":1755569,"name":"Young Chul Park","orcid":null,"position":5,"is_corresponding":false},{"id":1755564,"name":"Sang Yull Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Concurrent expression of heme oxygenase-1 and p53 in human retinal pigment epithelial cell line","abstract":"Heme oxygenase-1 (HO-1) is a stress-responsive protein that is known to regulate cellular functions such as cell proliferation, inflammation, and apoptosis. Here, we investigated the effects of HO activity on the expression of p53 in the human retinal pigment epithelium (RPE) cell line ARPE-19. Cobalt protoporphyrin (CoPP) induced the expression of both HO-1 and p53 without significant toxicity to the cells. In addition, the blockage of HO activity with the iron chelator DFO or with HO-1 siRNA inhibited the CoPP-induced expression of p53. Similarly, zinc protoporphyrin (ZnPP), an inhibitor of HO, suppressed p53 expression in ARPE-19 cells, although ZnPP increased the level of HO-1 protein while inhibiting HO activity. Also, CoPP-induced p53 expression was not affected by the formation of reactive oxygen species (ROS). Based on these results, we conclude that HO activity is involved in the regulation of p53 expression in a ROS-independent mechanism, and also suggest that the expression of p53 in ARPE-19 cells is associated with heme metabolites such as biliverdin/bilirubin, carbon monoxide, and iron produced by the activity of HO.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18042465","pmcid":null,"openalex_id":"https://openalex.org/W2076564495","authors":[],"funders":[],"total_grants":0,"fwci":0.2665,"citation_percentile":0.58761728,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":3},{"year":2016,"count":1},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X07025065?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X07025065?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2007.11.081","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18042465","host_type":"repository"}],"fields_of_study":["Heme Oxygenase-1 and Carbon Monoxide","Neonatal Health and Biochemistry","Alcohol Consumption and Health Effects","Cell Line","Gene Expression Regulation","Heme Oxygenase-1","Humans","Pigment Epithelium of Eye","Signal Transduction","Tumor Suppressor Protein p53"],"mesh_terms":["Cell Line","Gene Expression Regulation","Humans","Pigment Epithelium of Eye","Signal Transduction","Tumor Suppressor Protein p53","Heme Oxygenase-1"],"keywords":["COPP","Heme oxygenase","Biliverdin","Zinc protoporphyrin","Heme","Hemin","Cell biology","Biliverdin reductase","Cell culture","Protoporphyrin IX","Chemistry","Protoporphyrin","Retinal pigment epithelium","Apoptosis","Reactive oxygen species","Molecular biology","Biology","Retinal","Biochemistry","Photodynamic therapy","Enzyme"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T05:37:33.083366Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}