{"doi":"10.1016/j.bbrc.2007.04.052","title":"Involvement of Rabring7 in EGF receptor degradation as an E3 ligase","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2007,"id":617811,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1593400,"name":"Shigetsugu Hatakeyama","orcid":null,"position":1,"is_corresponding":false},{"id":1194702,"name":"Takuya Sasaki","orcid":"0000-0002-0576-7142","position":2,"is_corresponding":false},{"id":1593397,"name":"Ayuko Sakane","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Involvement of Rabring7 in EGF receptor degradation as an E3 ligase","abstract":"Rab7, a member of the Rab family small G proteins, is involved in the late stage of the endocytic pathway. We previously identified a Rab7 target protein, Rabring7, which contains a RING finger domain at its C termini, but the precise role of Rabring7 remains unknown. In this study, we demonstrate using an in vitro ubiquitination assay with recombinant E1 and E2 proteins that Rabring7 has E3 ligase activity and that it preferentially reacts with Ubc4 and Ubc5 as its E2 proteins. Rabring7 ubiquitinated itself but not Rab7, and a mutation at Cys-229 in the RING finger domain (Rabring7C229S) completely diminished its E3 ligase activity. In the ligand-induced degradation of EGF receptor (EGFR), Rabring7 accelerated the degradation of EGFR, whereas Rabring7C229S inhibited the degradation induced by cCbl, another E3 ligase. These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17462600","pmcid":null,"openalex_id":"https://openalex.org/W1987577112","authors":[],"funders":[{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"","title":null}],"total_grants":1,"fwci":1.2751,"citation_percentile":0.76796094,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":4},{"year":2014,"count":5},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":4},{"year":2020,"count":1},{"year":2022,"count":3},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X07007723?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X07007723?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2007.04.052","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17462600","host_type":"repository"}],"fields_of_study":["Cellular transport and secretion","Ubiquitin and proteasome pathways","Protein Degradation and Inhibitors","Cell Line","Endocytosis","Enzyme Activation","ErbB Receptors","Humans","Intracellular Signaling Peptides and Proteins","Kidney","Protein Binding","Ubiquitin-Protein Ligases"],"mesh_terms":["Cell Line","Endocytosis","Enzyme Activation","Humans","Kidney","Protein Binding","Ubiquitin-Protein Ligases","Intracellular Signaling Peptides and Proteins","ErbB Receptors"],"keywords":["Ubiquitin ligase","Endocytic cycle","Ubiquitin","Cell biology","Ring finger","DNA ligase","Ubiquitin-Protein Ligases","Biology","Receptor","Chemistry","Biochemistry","Molecular biology","Endocytosis","DNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:41:13.023520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}